66147-28-2Relevant academic research and scientific papers
Chlorination of 3β-hydroxyl-5-Δ steroids with anhydrous ferric chloride
Liu, Feng-Wu,Liu, Hong-Min,Zhang, Yan-Bing,Zhang, Jing-Yu,Tian, Li-Huan
, p. 825 - 830 (2005)
Treatment of 3β-hydroxyl-5-Δ steroids with anhydrous FeCl 3 in CH2Cl2 afforded reasonable yields of the corresponding alkyl chlorides with a retention of configurations. The structures of the chlorine-exchanging products were determined by NMR and HRMS spectra. The absolute configurations were confirmed by X-ray crystal analysis of 3β-chloro-androst-5-en-17-one. The generality and scope of the reaction were also investigated.
Etherification of Hydroxystereoids via Triflates
Belostotskii, Anatoly M.,Hassner, Alfred
, p. 5075 - 5076 (2007/10/02)
Triflates of saturated alcohols are useful in the alkylation of 3- and 17-hydroxysteroids in the presence of hindered amines.The etherification is successful even in those cases where other alkylating agents are noneffective.
