661471-72-3

Upstream product

• 661471-70-1 N²,2',3',5'-O-tetraacetyl-1-methylguanosine 
• 2140-65-0 1-methylguanosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 661471-71-2 N²-acetyl-1-methylguanosine 
• 118-00-3 G 

Downstream Products

• 661471-73-4 N²-acetyl-5'-O-(4,4'-dimethoxytrityl)-1-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]guanosine 

Relevant academic research and scientific papers

The Synthesis of 2′-O-[(Triisopropylsilyl)oxy] methyl (TOM) Phosphoramidites of Methylated Ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for Use in Automated RNA Solid-Phase Synthesis

The straightforward synthesis of eight methylated ribonucleoside phosphoramidites is described. These building blocks allow for incorporation of the naturally occuring nucleosides 1-methylguanosine (m1G), N 2-methylguanosine (m2G), N2N 2-dimethylguanosine (m22G), 1-methylinosine (m1I), 3-methyluridine (m3U), N4- methylcytidine (m4C), N6-methyladenosine (m6A), and N6,N6-dimethyladenosine (m62A) into oligoribonucleotides by automated RNA solid-phase synthesis. In all cases, the ribose 2′-hydroxyl group of the building blocks is masked by the recently introduced [(triisopropylsilyl)oxy]methyl (TOM) group.