661471-84-7Relevant academic research and scientific papers
The Synthesis of 2′-O-[(Triisopropylsilyl)oxy] methyl (TOM) Phosphoramidites of Methylated Ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for Use in Automated RNA Solid-Phase Synthesis
Hoebartner, Claudia,Kreutz, Christoph,Flecker, Elke,Ottenschlaeger, Elke,Pils, Werner,Grubmayr, Karl,Micura, Ronald
, p. 851 - 873 (2003)
The straightforward synthesis of eight methylated ribonucleoside phosphoramidites is described. These building blocks allow for incorporation of the naturally occuring nucleosides 1-methylguanosine (m1G), N 2-methylguanosine (m2G), N2N 2-dimethylguanosine (m22G), 1-methylinosine (m1I), 3-methyluridine (m3U), N4- methylcytidine (m4C), N6-methyladenosine (m6A), and N6,N6-dimethyladenosine (m62A) into oligoribonucleotides by automated RNA solid-phase synthesis. In all cases, the ribose 2′-hydroxyl group of the building blocks is masked by the recently introduced [(triisopropylsilyl)oxy]methyl (TOM) group.
Efficient photoactivation of a Diels-Alderase ribozyme
Nierth, Alexander,Singer, Marco,Jaeschke, Andres
experimental part, p. 7975 - 7977 (2011/01/04)
Here we report the first example of a photoactivatable ribozyme which catalyzes a bimolecular reaction of two small organic molecules with multiple turnover, under control of a photo-cleavable protecting group by exploiting the structural significance of
Modulation of RNA tertiary folding by incorporation of caged nucleotides
Hoebartner, Claudia,Silverman, Scott K.
, p. 7305 - 7309 (2007/10/03)
(Figure Presented) Knock it off: Individual RNA nucleotides with a caged nucleobase were incorporated, through their phosphoramidites, into a 160-mer RNA molecule that adopts a specific tertiary structure (see picture). Position-dependent local and global
