66148-17-2 Usage
Uses
Used in Research Applications:
MYOSMINE-2,4,5,6-D4 is used as a research compound for studying the properties and effects of myosmine. The deuterium labeling allows for enhanced detection and analysis of myosmine in various experimental settings.
Used in Toxicology Studies:
As myosmine has been suspected to be a tobacco-independent carcinogenic source, MYOSMINE-2,4,5,6-D4 can be used in toxicology studies to investigate its potential carcinogenic effects and mechanisms of action.
Used in Drug Metabolism and Pharmacokinetics:
The deuterated form of myosmine can be employed in drug metabolism and pharmacokinetics studies to understand how myosmine is processed and eliminated from the body, as well as its potential interactions with other compounds and drugs.
Used in Chemical Synthesis:
MYOSMINE-2,4,5,6-D4 can be utilized as a starting material or intermediate in the synthesis of other deuterated compounds or analogs of myosmine for various applications, including drug development and chemical research.
Used in Analytical Chemistry:
The deuterium labeling of MYOSMINE-2,4,5,6-D4 makes it an ideal internal standard for quantitative analysis of myosmine in complex samples, such as tobacco products, biological fluids, and environmental samples. This helps in accurate quantification and reduces the risk of false positives or negatives in analytical results.
Check Digit Verification of cas no
The CAS Registry Mumber 66148-17-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,1,4 and 8 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 66148-17:
(7*6)+(6*6)+(5*1)+(4*4)+(3*8)+(2*1)+(1*7)=132
132 % 10 = 2
So 66148-17-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H10N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7H,2,4,6H2/i1D,3D,5D,7D
66148-17-2Relevant academic research and scientific papers
Syntheses of isotope-labeled tobacco-specific nitrosamines and their metabolites
Desai, Dhimant,Krzeminski, Jacek,El-Bayoumy, Karam,Amin, Shantu
, p. 226 - 230 (2008/12/20)
We report here on the syntheses of three deuterium-labeled tobacco-specific nitrosamines namely [2,4,5,6-d4]nitroso-nornicotine([2,4,5,6-d 4]NNN), 4-(methylnitrosamino)-1-(3-[2,4,5,6-d4]pyridyl)-1- butanone ([2,4,5,6-d4]NNK), and 4-(methyl-nitrosamino)-1-(3-[2,4,5,6- d4]pyridyl)-1-butanol ([2,4,5,6-d4]NNAL). A metabolite of NNK and myosmine, 4-hydroxy-1-(3-[2,4,5,6-d4]pyridyl)-1-butanone, was also synthesized. The synthetic strategy reported here is similar to that reported in the literature for the preparation of corresponding unlabeled compounds. The commercially available [2,4,5,6-d4]ethylnicotinate was used as starting material. During the course of these syntheses [2,4,5,6-d 4]myosmme and [2,4,5,6-d4]nornicotine were obtained as stable intermediates. These isotope-labeled compounds are useful internal standards for quantification of TSNA and their metabolites in smokers in molecular epidemiological studies. Copyright
Synthesis of partially deuterated N-nitrosamines - New standards in tobacco-smoke analysis
Gaertner, Peter,Bica, Katharina,Einzinger, Christian
, p. 549 - 555 (2007/10/03)
N-Nitrosamines of tobacco alkaloids contribute to the cause of tobacco related cancers and, therefore, they are important analytes. Herein the preparation of four partially deuterated N-nitrosamines from simple, commercially available, deuterated educts is described, which can serve as useful standards in tobacco-smoke analysis. Springer-Verlag 2004.
