66154-58-3Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK
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Page/Page column 94, (2012/11/08)
Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders
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Page/Page column 44, (2009/04/24)
The invention relates to methods of using the compounds of the invention, including pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof, as well as pharmaceutical compositions comprising the same, in the treatment of Eph receptor-related (e.g., neurological) injuries and disorders. The invention also relates to modulating the activity of an Eph receptor in a cell, stimulating neural regeneration, and reversing neuronal degeneration, by administering a compound of the invention to a cell or subject in an effective amount.
INHIBITORS OF JAK2 KINASE
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Page/Page column 24-25, (2009/03/07)
Compounds inhibiting the bioactivity of the protein tyrosine kinase JAK2 are provided, along with methods of using the compounds in the treatment of malconditions wherein inhibition of JAK2 is medically indicated. Methods of preparation are also provided
Organic compounds
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Page/Page column 37, (2008/06/13)
The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.
PYRAZOLO[1,5-A]PYRIMIDIN-7-YL-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES
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Page/Page column 78, (2008/06/13)
The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.
Reactivity of 7-(2-Dimethylaminovinyl)pyrazolopyrimidines: Synthesis of Pyrazolopyridopyrimidine Derivatives as Potential Benzodiazepine Receptor Ligands. 2.
Bruni, Fabrizio,Selleri, Silvia,Costanzo, Annarella,Guerrini, Gabriella,Casilli, Maria Lucia,Giusti, Laura
, p. 291 - 298 (2007/10/02)
A series of pyrazolopyridopyrimidin-6-ones was obtained by reaction of ammonium acetate with ethyl 7-dimethylaminovinylpyrazolopyrimidine-6-carboxylates and these had been prepared from ethyl 7-methylpyrazolopyrimidine-6-carboxylates by reaction with dimethylformamide dimethylacetat.Under these conditions the compounds bearing a 2-hydroxy group were also O-alkylated.During the preparation of the ethyl 2-hydroxy-7-methyl-3-phenylpyrazolopyrimidine-6-carboxylate the corresponding 5-methyl isomer was isolated and identified.
