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Usage

Uses

Used in Pharmaceutical Industry:
Pyrrolidine, 2-[(4-methoxyphenyl)methyl]is employed as a key intermediate in the synthesis of various drugs, contributing to the development of therapeutic agents for a range of health conditions.
Used in Medicinal Chemistry:
Pyrrolidine, 2-[(4-methoxyphenyl)methyl]serves as a crucial component in medicinal chemistry, aiding in the design and synthesis of novel bioactive molecules with potential applications in treating central nervous system disorders, cancer, and infectious diseases.
It is imperative to exercise proper safety measures when handling Pyrrolidine, 2-[(4-methoxyphenyl)methyl]-, due to its potential health and environmental hazards if mismanaged.

Upstream product

• 26052-80-2 5-(4-methoxy-benzyl)-pyrrolidin-2-one 
• 133111-44-1 5-(4-methoxy-benzyl)-3,4-dihydro-2H-pyrrole 
• 154477-05-1 5-(4-methoxyphenyl)pent-4-yn-1-amine 
• 1119-51-3 bromopentene 
• 930-55-2 N-nitrosopyrrolidine 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 81593-68-2 4-[2-(4-Methoxy-benzyl)-pyrrolidin-1-yl]-4-oxo-butyric acid methyl ester 
• 81593-47-7 3,4-Dimethoxy-benzoic acid 4-[2-(4-methoxy-benzyl)-pyrrolidin-1-yl]-butyl ester 
• 81593-72-8 4-[2-(4-Methoxy-benzyl)-pyrrolidin-1-yl]-butan-1-ol 

Relevant academic research and scientific papers

Construction of azacycles by intramolecular amination of organoboronates and organobis(boronates)

Intramolecular amination of organoboronates occurs with a 1,2-metalate shift of an aminoboron ate complex to form azetidines, pyrrolidines, and piperidines. Bis(boronates) undergo site-selective amination to form boronate-containing azacycles. Enantiomerically enriched azacycles are formed with high stereospecificity.

The Cp2TiMe2-catalyzed intramolecular hydroamination/cyclization of aminoalkynes

Cp2TiMe2 has been found to be a competent catalyst for the intramolecular hydroamination/cyclization of aminoalkynes. In the presence of 5.0 mol% Cp2TiMe2, the hydroamination reactions proceed smoothly at 100-110°C to give five- and six-membered cyclic imines within 4-6 h. After subsequent reduction performed with zinc-modified NaBH3CN at room temperature cyclic amines can be isolated in good yields.

2-(Nuclearly-substituted)benzylpyrrolidines

2-Benzylpyrrolidines bearing from 1 to 4 nuclear substituents on the benzyl ring are pharmacologically active, particularly on the CNS, on blood pressure and on pain sensation for warm-blooded animals. They are synthesized, e.g., by reducing appropriate 2-benzylpyrrolidines and are formulated into medicament compositions according to established conventional techniques.