66162-43-4

Usage

Uses

Used in Organic Chemistry:
Pyrrolidine, 2-[(3,4-dimethoxyphenyl)methyl]is utilized as a building block in organic chemistry for the synthesis of other chemicals. Its distinctive structure allows it to serve as a key component in creating a variety of complex molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Pyrrolidine, 2-[(3,4-dimethoxyphenyl)methyl]is considered a potential drug candidate. Its specific chemical properties make it a promising starting point for the development of new therapeutic agents with potential applications in medicine.
Safety Precautions:
As with all chemicals, Pyrrolidine, 2-[(3,4-dimethoxyphenyl)methyl]should be handled and used with appropriate safety measures to minimize any potential hazards. Proper care must be taken to ensure that its unique properties do not lead to unintended consequences during its application in research and development processes.

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 92076-93-2 N-trifluoroacetyl-DL-proline 
• 92076-92-1 (-)-N-(trifluoroacetyl)prolyl chloride 
• 91994-59-1 -3,4-dimethoxybenzene 
• 82590-36-1 (Z)-5-(3,4-Dimethoxy-phenyl)-4-nitro-pent-4-enoic acid ethyl ester 
• 82590-44-1 4-Amino-5-(3,4-dimethoxy-phenyl)-pentan-1-ol 
• 91994-66-0 1-[2-(3,4-Dimethoxy-benzyl)-pyrrolidin-1-yl]-2,2,2-trifluoro-ethanone 

Downstream Products

• 82589-49-9 2-(3,4-Dimethoxy-benzyl)-pyrrolidine-1-carbaldehyde 
• 82589-55-7 7,8-Dimethoxy-1,2,3,5,10,10a-hexahydropyrrolo<1,2-b>isoquinoline 

Relevant academic research and scientific papers

Friedel-Crafts Acylation with N-(Trifluoroacetyl)-α-amino Acid Chlorides. Application to the Preparation of β-Arylalkylamines and 3-Substituted 1,2,3,4-Tetrahydroisoquinolines

Several N-(trifluoroacetyl)-α-amino acid chlorides have been reacted with benzene, anisole, and veratrole in the presence of AlCl3 or SnCl4 to produce the corresponding aromatic ketones in fair to high yields.The products are reductible under neutral or acidic conditions to the corresponding N-(trifluoroacetyl)-β-hydroxy-β-arylakylamines or N-(trifluoroacetyl)-β-arylalkylamines.The latter can be readily detrifluoroacetylated by mild basic hydrolysis and thence converted to the corresponding 3-substituted 1,2,3,4-tetrahydroisoquinolines by condensation with formaldehyde.

Synthesis of Hexahydropyrroloisoquinolines - Analogs of Phenanthroindolizidine Anticancer Alkaloids

A convenient preparative route has been developed for the synthesis of hexahydropyrroloisoquinolines involving condensation of an araldehyde with ethyl 4-nitrobutanoate followed by LAH reduction and subsequent cyclization with H2SO4 to 2-arylmethylpyrrolidines.The latter on formylation and Bischler-Napieralsky cyclization followed by NaBH4 reduction give the required pyrroloisoquinolines.Using this method, 8-methoxy-1,2,3,5,10,10a-hexahydropyrroloisoquinoline (IXa); 7,8-dimethoxy-1,2,3,5,10,10a-hexahydropyrroloisoquinoline (IXb); 7,9,10,11,11a,12-hexahydrobenzopyrroloisoquinoline (Xa); 3-methoxy-7,9,10,11,11a,12-hexahydrobenzopyrroloisoquinoline (Xb); 7,7a,8,9,10,12-hexahydrobenzopyrroloisoquinoline (XIa); 3-methoxy-7,7a,8,9,10,12-hexahydrobenzopyrroloisoquinoline (XIb) and 2,3-dimethoxy-7,7a,8,9,10,12-hexahydrobenzopyrroloisoquinoline (XIc) have been synthesized.None of these compounds has shown any noteworthy anticancer activity while few have exhibited interesting antihistaminic, β-blocking, hypertensive, antiinflammatory and antireserpine activities.

2-(Nuclearly-substituted)benzylpyrrolidines

2-Benzylpyrrolidines bearing from 1 to 4 nuclear substituents on the benzyl ring are pharmacologically active, particularly on the CNS, on blood pressure and on pain sensation for warm-blooded animals. They are synthesized, e.g., by reducing appropriate 2-benzylpyrrolidines and are formulated into medicament compositions according to established conventional techniques.