66163-08-4Relevant academic research and scientific papers
Mild conditions for the synthesis of functionalized pyrrolidines via Pd-catalyzed carboamination reactions
Bertrand, Myra Beaudoin,Leathen, Matthew L.,Wolfe, John P.
, p. 457 - 460 (2007)
The palladium-catalyzed carboamination of N-protected y-aminoalkenes with aryl bromides and triflates has been achieved under new, mild reaction conditions using the weak base Cs2CO3 in dioxane solvent. These reactions tolerate a wid
Mild conditions for Pd-catalyzed carboamination of N-protected hex-4-enylamines and 1-, 3-, and 4-substituted pent-4-enylamines. Scope, limitations, and mechanism of pyrrolidine formation
Bertrand, Myra Beaudoin,Neukom, Joshua D.,Wolfe, John P.
supporting information; experimental part, p. 8851 - 8860 (2009/04/11)
(Chemical Equation Presented) The use of the weak base Cs 2CO3 in Pd-catalyzed carboamination reactions of N-protected γ-aminoalkenes with aryl bromides leads to greatly increased tolerance of functional groups and alkene substitutio
2-(Nuclearly-substituted)benzylpyrrolidines
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, (2015/02/20)
2-Benzylpyrrolidines bearing from 1 to 4 nuclear substituents on the benzyl ring are pharmacologically active, particularly on the CNS, on blood pressure and on pain sensation for warm-blooded animals. They are synthesized, e.g., by reducing appropriate 2-benzylpyrrolidines and are formulated into medicament compositions according to established conventional techniques.
