6617-65-8Relevant academic research and scientific papers
Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines
Leon, Leticia G.,Donadel, Osvaldo J.,Tonn, Carlos E.,Padron, Jose M.
experimental part, p. 6251 - 6256 (2011/02/25)
A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog induced considerably growth inhibition in the range 1.9-4.5 μM. Cell cycle studies for tessaric acid derivatives indicated a prominent arrest of the cell cycle at the G2/M phase. Damage to the cells was permanent as determine by the so called 24+24 drug schedule.
SESQUITERPENOIDS FROM Dittrichia viscosa (L.) GREUTER. THEIR STRUCTURE AND DETERRENT ACTIVITY
Daniewski, Wlodzimierz M.,Kroszczynski, Wojciech,Bloszyk, Elzbieta,Drozdz, Bohdan,Nawrot, Jan,et al.
, p. 1710 - 1721 (2007/10/02)
In addition to the earlier described inuviscolide (II), the sesquiterpenic vachanic (V) and 2α-hydroxyisocostic (VII) acids, as well as carabron (VIII) and the so far undescribed sesquiterpenic lactone 11αH,13-dihydroconfertin were also isolated from Dittrichia viscosa (L.) GREUTER.For the last mentioned lactone the structure IX has been derived.The structure of vachanic acid (V) was confirmed by X-ray structural analysis.Compounds V to VII were tested for their deterrent (antifeedant) activity against selected insect pests living in corn stores, and they generally had a high activity.
