66172-75-6Relevant academic research and scientific papers
Long-acting xanthine bronchodilators and antiallergy agents
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, (2008/06/13)
Prolonged bronchodilation and prolonged inhibition of allergic mediator release in mammals are produced by administering an effective amount of a substituted xanthine compound having the formula: STR1 wherein: R1 = methyl R3 = c4 -c7 alkyl, C4 -C7 cycloalkylalkyl C4 -C7 alkenyl, C4 -C7 alkynyl, or C4 -C7 cycloalkyl R8 = c1 -c2 alkyl These compounds are useful in the treatment of bronchial asthma and other bronchospastic and allergic diseases. The compounds are also novel. The bronchodilator and antiallergy agents may be administered in the form of tablets, capsules, aerosols, solutions, suspensions or suppositories.
Xanthine compounds and method of treating bronchospastic and allergic diseases
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, (2008/06/13)
Bronchial asthma and other bronchospastic and allergic diseases are treated by administering an effective amount of a substituted xanthine compound having the formula: STR1 wherein: R1 = C1 -C3 alkyl, R3 = c1 -c7 alkyl, C3 -C7 alkenyl, C3 -C7 alkynyl, C3 -C7 cycloalkyl or C4 -C7 cycloalkylalkyl, R8 = h, c1 -c4 alkyl, C3 -C4 alkenyl, C3 -C4 alkynyl or C3 -C4 cycloalkyl, R = c1 -c4 alkyl, 2-halo C2 -C3 alkyl, or phenyl Novel and preferred bronchodilator and antiallergy compounds are disclosed having the formula STR2 wherein: R1 = C1 -C2 alkyl R3 = ch2 --(c3 -c4 alkyl),--CH2 --(C3 -C4 alkenyl), or --CH2 --(C3 -C4 cycloalkyl) R8 = h, c1 -c2 alkyl, R = c1 -c4 alkyl, 2-halo C2 -C3 alkyl, or phenyl The bronchodilator and antiallergy agents may be administered in the form of tablets, capsules or aerosols.
