66179-55-3Relevant academic research and scientific papers
A novel, simple and practical protocol for N - Protected - α - Amino hydroxamic acids
Reddy, G. Vidyasagar
, p. 3613 - 3619 (1999)
A facile single step methodology for the preparation of N-Protected-α- amino hydroxamic acids from readily accessible N-protected oxazolidinones using hydroxylamine hydrochloride and triethylamine is described.
Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors
Su, Li,Jia, Yuping,Zhang, Lei,Xu, Yingying,Fang, Hao,Xu, Wenfang
, p. 3807 - 3815 (2012/08/27)
A series of amino acid ureido derivatives as aminopeptidase N (APN/CD13) inhibitors were synthesized and evaluated for their APN inhibitory activities and anti-cancer effects. The results showed that most of these amino acid ureido derivatives exhibited good inhibition against APN, several of which were better than Bestatin. The most active compound 12j (IC50 = 1.1 μM, compared with Bestatin IC50 = 8.1 μM) not only possessed much better APN inhibitory activity and anti-proliferation effect on cancer cells, but also exhibited significant block effect of human cancer cell invasion compared with the positive control, Bestatin. These amino acid ureido derivatives could be possibly developed as new APN inhibitors for cancer chemotherapy in the future.
Convenient synthesis of a library of discrete hydroxamic acids using the hydroxythiophenol (Marshall) resin
Choi, Jinil,Park, Jewn Giew,Pang, Yuan-Ping
, p. 1103 - 1106 (2008/09/17)
Several resins have reportedly been used to synthesize hydroxamic acids except for the hydroxythiophenol (Marshall) resin. Herein, we report the use of the Marshall resin to synthesize hydroxamic acids from carboxylic acids and its application to convert a library of 14 discrete aliphatic and aromatic carboxylic acids including N-protected amino acids to their corresponding hydroxamic acids in good yields.
Solid phase synthesis of hydroxamic acids
Dankwardt, Sharon M.
, p. 761 - 761 (2007/10/03)
The solid phase synthesis of hydroxamic acids is presented. Carboxylic acid ester linked, polymer-supported CBZ-protected amino acids were displaced from the resin with aqueous hydroxylamine to provide the corresponding hydroxamic acids.
