6618-43-5

Basic information

• Product Name: Δ¹⁶-androstene
• Synonyms: Δ¹⁶-androstene
• CAS NO: 6618-43-5
• Molecular Weight: 258.447
• Mol File: 6618-43-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Δ¹⁶-androstene(CAS DataBase Reference)
• NIST Chemistry Reference: Δ¹⁶-androstene(6618-43-5)
• EPA Substance Registry System: Δ¹⁶-androstene(6618-43-5)

Safety Data

• Hazardous Substances Data: 6618-43-5(Hazardous Substances Data)

Upstream product

• 26313-26-8 17-iodo-5α-androst-16-ene 
• 868-85-9 Dimethyl phosphite 
• 762-04-9 phosphonic acid diethyl ester 
• 1809-20-7 diisopropyl hydrogenphosphonate 

Downstream Products

• 438-22-2 (5α)-androstane 
• 19037-37-7 (5α)androstanol-17α 
• 1032-14-0 (5α)androstanol-16α 

Relevant articles and documents

Steroidal alkenylphosphonates via palladium-catalyzed coupling reactions

The palladium-catalyzed coupling of various 17-iodo-Δ16 steroids (17-iodo-androst-16-ene, 17-iodo-4-methyl-4-aza-androst-16-en-3-one, and 17-iodo-4-aza-androst-16-en-3-one) with dialkyl phosphites (dimethyl phosphite, diethyl phosphite, and diisopropyl phosphite) was examined in detail.The only successful condition for homogeneous coupling involved carrying out the reaction in the absence of any solvents.A large excess of dialkyl phosphite was used, which means that the phosphite itself acted as a solvent.Eight new androst-16-ene derivatives with phosphonate groups at C-17 were synthesized and characterized.These steroids are of pharmacological interest as potential 5α-reductase inhibitors.Under the same conditions, methylation of lactam NH was observed using dimethyl phosphite. - Keywords: coupling reaction of steroids; steroidal alkenylphosphonates; homogeneous palladium(0) catalysts