66183-76-4

Upstream product

• 59749-46-1 (R)-1-(4-fluorobenzyl)-2-pyrrolidinone-5-carboxamide 
• 344-25-2 D-Prolin 
• 459-46-1 4-Fluorobenzyl bromide 
• 114812-38-3 4-fluorobenzyl (R)-1-(4-fluorobenzyl)-2-pyrrolidinecarboxylate 
• 114812-36-1 (+)-(R)-1-(4-fluorobenzyl)-2-pyrrolidinecarboxamide 

Downstream Products

• 107188-82-9 5-Bromo-N-[(R)-1-(4-fluoro-benzyl)-pyrrolidin-2-ylmethyl]-2,3-dimethoxy-benzamide 
• 132020-37-2 3-Bromo-N-[(R)-1-(4-fluoro-benzyl)-pyrrolidin-2-ylmethyl]-2,5,6-trimethoxy-benzamide 
• 132046-31-2 (+)-(R)-3,5-dichloro-N-{[1-(4-fluorobenzyl)-2-pyrrolidinyl]methyl}-2,6-dimethoxybenzamide 
• 132020-43-0 3-Bromo-N-[(R)-1-(4-fluoro-benzyl)-pyrrolidin-2-ylmethyl]-2-hydroxy-6-methoxy-benzamide 
• 132020-35-0 3-Chloro-5-ethyl-N-[(R)-1-(4-fluoro-benzyl)-pyrrolidin-2-ylmethyl]-6-hydroxy-2-methoxy-benzamide 

Relevant academic research and scientific papers

Enantiometric iodobenzamides.

Novel iodine-substituted benzamide derivatives of formula I wherein R1 is a hydrogen atom, a lower alkyl group consisting of 1 to 4 carbon atoms, a cycloalkyl group consisting of 3 to 7 carbon atoms, an alkenyl group consisting of 2 to 4 carbon atoms, an alkynyl group consisting of 2 to 4 carbon atoms, a phenyl group, a halogen substituted phenyl group, or an enantiomer or pharmaceutically suitable salt thereof, exhibit high blocking activity and specifity for the dopamine D-2 receptor.

Efficient Stereoconservative Syntheses of 1-Substituted (S)- and (R)-2-Aminomethylpyrrolidines

Three-step stereoconservative syntheses of chiral 1-substituted 2-aminomethylpyrrolidines with high optical purities from D- or L-proline are described.The key intermediates, 1-substituted prolinamides, were obtained by N,O-dialkylation of proline followed by ammonolysis or by 1-alkylation of prolinamide.Reduction furnished the optically pure (about 99percent e.e.) pyrrolidine derivatives, which are useful as intermediates in the preparation of antipsychotic substituted benzamides.