66186-69-4

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 1076-95-5 p-methoxyphenylglyoxal 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 930278-35-6 (R)-2,2-diethoxy-1-(4-methoxyphenyl)ethanol 
• 851136-37-3 (R)-N-(1-(4-methoxyphenyl)-2-oxoethyl)benzamide 

Relevant academic research and scientific papers

Direct asymmetric reductive amination of α-keto acetals: A platform for synthesizing diverse α-functionalized amines

We report an efficient and straightforward method to synthesize enantio-enriched N-unprotected α-amino acetals via ruthenium-catalyzed direct asymmetric reductive amination. The α-amino acetal products are versatile and valuable platform molecules that can be converted to the corresponding α-amino acids, amino alcohols, and other derivatives by convenient transformations.

One-pot synthesis of α-ketoacetals from aryl methyl ketones in the presence of selenous acid catalyzed by boron trifluoride etherate

A simple and efficient one-pot preparation of α-ketoacetals from substituted acetophenones and triethylorthoformate in the presence of H2SeO3 and BF3·Et2O as catalyst has been developed. The desired products are obtained in good yields by a simple protocol involving neat and mild reaction conditions. The present methodology provides an attractive alternative method for the preparation of α-ketoacetal derivatives.

[1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUND, PREPARATION METHOD AND USE THEREOF

The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition comprising a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality.

Catalytic asymmetric cyanosilylation of ketones with chiral Lewis base

The development of broadly applicable and practical catalytic approaches for the enantioselective creation of quaternary stereocenters remains a highly desirable yet challenging goal. In this Communication, we describe a highly enantioselective cyanosilylation of acetal ketones (α,α-dialkoxy ketones) catalyzed by modified cinchona alkaloids. This reaction is the first highly enantioselective cyanosilylation of ketones catalyzed by an organic chiral Lewis base and is found to be highly efficient with acetal ketones bearing a broad range of alkyl, aryl, alkenyl, and alkynyl substituents. This new catalytic asymmetric reaction, coupled with the versatility of the acetal functionality, provides a broadly useful synthetic method for chiral building blocks bearing quaternary stereocenters. Acetal ketones, readily accessible but previously unexplored in asymmetric synthesis, demonstrate unusual reactivity and selectivity toward the nucleophilic cyanosilylation, thereby suggesting that they may be interesting substrates for other catalytic enantioselective reactions. Copyright