66188-46-3Relevant academic research and scientific papers
β2, 2-Amino Acid N-Carboxyanhydrides Relying on Sequential Enantioselective C(4)-Functionalization of Pyrrolidin-2,3-diones and Regioselective Baeyer–Villiger Oxidation
Badiola, Eider,Olaizola, Iurre,Vázquez, Ana,Vera, Silvia,Mielgo, Antonia,Palomo, Claudio
, p. 8185 - 8195 (2017)
A catalytic enantioselective entry to β2, 2-amino acids enabling their direct coupling with nucleophiles is described. The approach is based upon an effective bifunctional Br?nsted base catalyzed construction of a quaternary carbon stereocenter at C4 position of pyrrolidin-2,3-diones. Subsequent regioselective Baeyer–Villiger oxidation of the resultant adducts gives β2, 2-amino acid N-carboxyanhydrides as the reactive species, which can further react with nucleophiles. Following this strategy both, β2, 2-amino acid derivatives with different functionalities at the newly created stereocenter, and spirocyclic structures can be efficiently prepared.
Novel 3-hydroxy-pyrrolin-2-one derivatives
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, (2008/06/13)
The present invention is concerned with novel 3-hydroxy-pyrrolin-2-one derivatives and with the preparation thereof.
