66191-74-0

Upstream product

• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 2042-37-7 o-cyanobromobenzene 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 66192-12-9 diethyl 2-(2-bromobenzyl)-2-methylmalonate 
• 66191-87-5 3-(2-Bromo-phenyl)-2-methyl-propionic acid methyl ester 

Relevant academic research and scientific papers

Palladium-catalyzed β-arylation of silyl ketene acetals and application to the synthesis of benzo-fused δ-lactones

Silyl ketene acetals are shown to be competent nucleophiles in Pd-catalyzed migrative C(sp3)-H arylations. Compared to the parent ester lithium enolates, they possess decreased reactivity but enhanced chemoselectivity. This behavior was exploited through the synthesis of valuable benzo-fused δ-lactones such as 1-isochromanones and dihydrocoumarins.