66192-24-3

Usage

Chemical Properties

Colourless Oil

InChI:InChI=1/C7H5Br2Cl/c8-4-5-3-6(10)1-2-7(5)9/h1-3H,4H2

Upstream product

• 347165-36-0 ethyl 1-cyclohexyl-2-(4-hydroxyphenyl)-1H-benzimidazole-5-carboxylate 
• 14495-51-3 2-bromo-5-chlorotoluene 
• 108-41-8 1-chloro-3-methylbenzene 
• 19398-61-9 2,5-dichlorotoluene 
• 23399-70-4 4-chloro-1-iodo-2-methylbenzene 

Downstream Products

• 66192-18-5 2-(2-Bromo-5-chloro-benzyl)-malonic acid diethyl ester 
• 66192-19-6 2-(2-Bromo-5-chloro-benzyl)-2-methyl-malonic acid diethyl ester 
• 66192-20-9 2-(2-Bromo-5-chloro-benzyl)-2-ethyl-malonic acid diethyl ester 
• 496790-58-0 2-(benzhydrylidene-amino)-3-(2-bromo-5-chloro-phenyl)-propionic acid tert-butyl ester 
• 174265-12-4 2-bromo-5-chlorobenzaldehyde 
• 347165-37-1 2-[4-(2-bromo-5-chlorobenzyloxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid ethyl ester 
• 872314-71-1 1-(2-bromo-5-chlorobenzyloxy)-4-(2-methoxyethoxy)benzene 
• 1021173-21-6 diethyl (2-bromo-5-chlorophenyl)methylphosphonate 
• 1003020-18-5 N-(4-methoxybenzyl)(2-bromo-5-chlorophenyl)methanamine 
• 875446-61-0 (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-(2-bromo-5-chlorobenzyl)-4-methyl-1,3-oxazolidin-2-one 
• 1027343-46-9 C₁₈H₂₆BrClN₂O₂ 
• 1033820-55-1 C₁₇H₁₆BrClO₃ 
• 1135372-43-8 5,5-bis(2-bromo-5-chlorobenzyl)-1,3-dimethylbarbituric acid 
• 1210056-93-1 2-(azidomethyl)-1-bromo-4-chlorobenzene 

Relevant academic research and scientific papers

DIBENZOHETEROCYCLIC COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF

A dibenzoheterocyclic compound wherein band gaps of HOMO and LUMO energy levels of the dibenzoheterocyclic compound are wide, light can be emitted in a deep blue light-emitting region; and the LUMO energy level of the dibenzoheterocyclic compound is low, so the LUMO energy level matches with an electron transport layer for electrons injection and transport. The dibenzoheterocyclic compound has hole transport performance, so as a light-emitting layer material, the dibenzoheterocyclic compound balances the ratio of electrons to holes in a light-emitting layer increasing the combination probability and improving the device light-emitting efficiency. The spatial configuration of the dibenzoheterocyclic compound avoids material stacking molecules, reduces annihilation of excitons, and inhibits efficiency roll-off. The dibenzoheterocyclic compound has thermal stability, so deep blue light can be emitted efficiently and stably. With an organic light-emitting diode and a deep blue light-emitting device with high light-emitting efficiency, low working voltage can be obtained.

Cross-coupling strategy for the synthesis of diazocines

Ethylene bridged azobenzenes are novel, promising molecular switches that are thermodynamically more stable in the (Z) than in the (E) configuration, contrary to the linear azobenzene. However, their previous synthetic routes were often not general, and yields were poorly reproducible, and sometimes very low. Here we present a new synthetic strategy that is both versatile and reliable. Starting from widely available 2-bromobenzyl bromides, the designated molecules can be obtained in three simple steps.

tBuOK-Promoted Cyclization of Imines with Aryl Halides

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

A two-benzo heterocyclic compound and its preparation method and application (by machine translation)

The present invention discloses a two-benzo heterocyclic compound, of formula (I) as shown in the structure. Dibenzofluorene and heterocyclic compounds of the LUMO energy level is low, with the electronic transmission material good matching, favorable to electronic injection and transmission. Dibenzofluorene and heterocyclic compound having good hole transmission performance, as luminescent material in the luminescent layer can balance the proportion of electrons and holes, improve the composite probability, make the device light-emitting efficiency is enhanced. Dibenzofluorene and heterocyclic compounds of space configuration can avoid material molecular stacking, and then prevent the intermolecular energy transfer result in high-energy exciton generation, reduce the exciton annihilation, inhibit efficiency roll-off. At the same time, dibenzo heterocyclic compound having good thermal stability, can achieve high-efficiency stable blue-light. The invention also discloses an organic electroluminescent device, at least one functional layer containing the above-mentioned in-diazepine heterocyclic compound, can be obtained with high blue light emitting efficiency and low operating voltage of blue light device. (by machine translation)

COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK

This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.

Rhodium-Catalyzed, Enantioselective Hydroacylation of ortho-Allylbenzaldehydes

The development of a rhodium catalyst for endo- and enantioselective hydroacylation of ortho-allylbenzaldehydes is reported. A catalyst generated in situ from [Rh(COD)Cl]2, (R)-DTBM-SEGPHOS, and NaBARF promotes the desired hydroacylation reactions and minimizes the formation of byproducts from competitive alkene isomerization and ene/dehydration pathways. These rhodium-catalyzed processes generate the 3,4-dihydronaphthalen-1(2H)-one products in moderate-to-high yields (49-91%) with excellent enantioselectivities (96-99% ee).

NEW CRTH2 ANTAGONISTS

The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

Copper-catalyzed domino coupling reaction: An efficient method to synthesize oxindoles

An efficient and novel procedure for a copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applied to synthesize horsfiline and coerulescine in few steps with high total yields. The Royal Society of Chemistry 2012.

Palladium-catalyzed intramolecular decarboxylative coupling of arene carboxylic acids/esters with aryl bromides

Give me a ring? An efficient approach has been developed for the intramolecular decarboxylative coupling of arene carboxylic acids/esters with aryl bromides catalyzed by palladium (see scheme). From a synthetic viewpoint, this method is highly attractive because the catalyst loading is low, the optimized reaction conditions are mild, and the substrate scope is broad. Copyright

Synthesis of benzo- and naphtho-fused bicyclo[n.3.1]alkane frameworks with a bridgehead nitrogen function by palladium-catalyzed intramolecular α′-arylation of α-nitroketones

The C-alkylation of cyclic α-nitroketones with α-halobenzyl halides in the presence of DBU followed by a Pd-catalyzed intramolecular C-arylation afforded benzo-and naphtho-fused bicyclo[n.3.1]alkane derivatives (n = 3, 4, 5) in excellent overall yields for the two-step sequence. In some of the reactions starting from α-nitrocyclooctanone, the major products were fused indane derivatives arising from an intramolecular attack of an intermediate Pd species onto the carbonyl group, followed by elimination.