66192-24-3

Basic information

• Product Name: 2-Bromo-1-bromomethyl-5-chlorobenzene
• Synonyms: 2-Bromo-1-bromomethyl-5-chlorobenzene;Benzene, 1-bromo-2-(bromomethyl)-4-chloro-
• CAS NO: 66192-24-3
• Molecular Formula: C₇H₅Br₂Cl
• Molecular Weight: 284.3756
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 66192-24-3.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 281.542°C at 760 mmHg
• Flash Point: 138.303°C
• Appearance: /
• Density: 1.933
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 2-Bromo-1-bromomethyl-5-chlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-1-bromomethyl-5-chlorobenzene(66192-24-3)
• EPA Substance Registry System: 2-Bromo-1-bromomethyl-5-chlorobenzene(66192-24-3)

Safety Data

• Hazardous Substances Data: 66192-24-3(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

InChI:InChI=1/C7H5Br2Cl/c8-4-5-3-6(10)1-2-7(5)9/h1-3H,4H2

Upstream product

• 14495-51-3 2-bromo-5-chlorotoluene 
• 19398-61-9 2,5-dichlorotoluene 
• 108-41-8 1-chloro-3-methylbenzene 
• 23399-70-4 4-chloro-1-iodo-2-methylbenzene 
• 347165-36-0 ethyl 1-cyclohexyl-2-(4-hydroxyphenyl)-1H-benzimidazole-5-carboxylate 

Downstream Products

• 1003020-18-5 N-(4-methoxybenzyl)(2-bromo-5-chlorophenyl)methanamine 
• 1027343-46-9 C₁₈H₂₆BrClN₂O₂ 
• 1033820-55-1 C₁₇H₁₆BrClO₃ 
• 1300038-78-1 2-(2-bromo-5-chlorobenzyl)-2-nitrocyclooctanone 
• 1300038-63-4 2-bromo-5-chlorobenzyl iodide 
• 1300038-71-4 2-(2-bromo-5-chlorobenzyl)-2-nitrocycloheptanone 
• 1420532-65-5 4-(2-bromo-5-chlorobenzyl)-2,2,6,6-tetramethylheptane-3,5-dione 
• 66192-20-9 2-(2-Bromo-5-chloro-benzyl)-2-ethyl-malonic acid diethyl ester 
• 66192-19-6 2-(2-Bromo-5-chloro-benzyl)-2-methyl-malonic acid diethyl ester 
• 66192-18-5 2-(2-Bromo-5-chloro-benzyl)-malonic acid diethyl ester 
• 1619256-38-0 4-chloro-2-(2-methylallyl)benzaldehyde 

Relevant articles and documents

DIBENZOHETEROCYCLIC COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF

A dibenzoheterocyclic compound wherein band gaps of HOMO and LUMO energy levels of the dibenzoheterocyclic compound are wide, light can be emitted in a deep blue light-emitting region; and the LUMO energy level of the dibenzoheterocyclic compound is low, so the LUMO energy level matches with an electron transport layer for electrons injection and transport. The dibenzoheterocyclic compound has hole transport performance, so as a light-emitting layer material, the dibenzoheterocyclic compound balances the ratio of electrons to holes in a light-emitting layer increasing the combination probability and improving the device light-emitting efficiency. The spatial configuration of the dibenzoheterocyclic compound avoids material stacking molecules, reduces annihilation of excitons, and inhibits efficiency roll-off. The dibenzoheterocyclic compound has thermal stability, so deep blue light can be emitted efficiently and stably. With an organic light-emitting diode and a deep blue light-emitting device with high light-emitting efficiency, low working voltage can be obtained.

tBuOK-Promoted Cyclization of Imines with Aryl Halides

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK

This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.