66200-62-2Relevant articles and documents
Substituted 4,5,6,7-tetrahydrothienopyridines as KCNQ2/3 Modulators
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Page/Page column 29, (2010/05/13)
Substituted tetrahydrothienopyridines corresponding to formula (1) in which A1 through A3 and R1 through R12 have defined meanings, pharmaceutical compositions comprising such compounds, a process for preparing such compounds and the use of such compounds in treatment or inhibition of conditions mediated by the KCNQ 2/3 K+ channel, e.g., pain.
Nouvelles voies d'acces a des aryl-4 thienopyridines et a des aryl-7 thienopyridines
Maffrand, Jean-Pierre,Biogegrain, Robert,Courregelongue, Jean,Ferrand, Gerard,Frehel, Daniel
, p. 727 - 734 (2007/10/02)
4-Arylthienopyridines and 7-arylthienopyridines have been prepared by heating in polyphosphoric acid 2-(2-thenylamino)-1-arylethanols or propanols and 2-(3-thenylamino)-1-arylethanols and propanols, respectively.Under the Beckmann rearrangement conditions, oximes of 4-aryl-4,5-dihydro-6H-cyclopentathiophen-6-one lead to 4-aryl-4,5-dihydro-6H-thienopyridin-7-one.