662148-36-9Relevant academic research and scientific papers
Synthesis of Benzo[b]imidazo[1,5-d][1,5]-thiazepines. Derivatives of a Novel Ring System
Petrova,Petrov,Antonova,Kalcheva
, p. 4355 - 4366 (2007/10/03)
Derivatives of a novel tricyclic system having a 1,5-benzothiazepine skeleton are described. A method for synthesis of the title compounds 5, consisted of an intramolecular cyclization of 1-(2-carboxymethylthiophenyl)-2H-imidazol-2-ones 4 in PPA, is presented. Compounds 4 were prepared by a reaction of 1-(2-mercaptophenyl)-2H-imidazol-2-ones 3 with chloroacetic acid. 2H-Imidazolones 3 were obtained by a ring transformation of substituted 2(3H)-benzothiazolones 2 in reactions with primary amines. The method is convenient because of its simplicity and good yields.
