662154-13-4 Usage
General Description
1-(2-Bromophenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde is a chemical compound with the molecular formula C13H12BrNO. It belongs to the class of aldehydes and contains a pyrrole ring system with a bromophenyl group attached. 1-(2-BROMOPHENYL)-2,5-DIMETHYL-1H-PYRROLE-3-CARBALDEHYDE is commonly used in organic synthesis and pharmaceutical research. It may also have potential applications in the development of new drugs and materials due to its unique structural features. The presence of the aldehyde functional group makes it a versatile building block for the synthesis of more complex organic molecules. However, it is important to handle this chemical with care as it may pose health and environmental hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 662154-13-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,2,1,5 and 4 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 662154-13:
(8*6)+(7*6)+(6*2)+(5*1)+(4*5)+(3*4)+(2*1)+(1*3)=144
144 % 10 = 4
So 662154-13-4 is a valid CAS Registry Number.
662154-13-4Relevant articles and documents
Design and development of pyrrole carbaldehyde: An effective pharmacophore for enoyl-ACP reductase
Joshi, Shrinivas D.,Kumar, Devendra,More, Uttam A.,Yang, Kap Seung,Aminabhavi, Tejraj M.
, p. 672 - 689 (2016/03/08)
Enoyl-ACP reductase is the key enzyme involved in FAS-II synthesis of mycolic acid in bacterial cell wall and is a promising target for discovering new chemical entity. The designed pharmacophores are the possible better tools to combat mutation in enoyl-ACP enzyme, which leads to a decrease in volume of triclosan binding site. Compound 3a showed H-bonding interactions similar to that of triclosan with enoyl-ACP enzyme and with a better docking score (C score 8.81), while the compound 3f showed additional interaction with MET98.H amino acid residue. The 3D-QSAR computations also support the docking study to develop novel pyrrole-based derivatives. Graphical abstract: Molecular docking 3D-QSAR studies and synthesis of active analogs of pyrrole carbaldehyde as better receptor fit pharmacophore for enoyl-ACP reductase along with in vitro antitubercular activity. (Figure Presented).
