66230-05-5

Basic information

• Product Name: Benzeneacetyl chloride, 4-chloro-a-(1-methylethyl)-, (S)-
• CAS NO: 66230-05-5
• Molecular Formula: C11H12Cl2O
• Molecular Weight: 231.122
• Mol File: 66230-05-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzeneacetyl chloride, 4-chloro-a-(1-methylethyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetyl chloride, 4-chloro-a-(1-methylethyl)-, (S)-(66230-05-5)
• EPA Substance Registry System: Benzeneacetyl chloride, 4-chloro-a-(1-methylethyl)-, (S)-(66230-05-5)

Safety Data

• Hazardous Substances Data: 66230-05-5(Hazardous Substances Data)

Upstream product

• 55332-38-2 S-isopropyl-4-chlorophenylacetic acid 

Downstream Products

• 66230-04-4 esfenvalerate 
• 66267-77-4 [R]-alpha-cyano-3-phenoxybenzyl [S]-2-(4-chlorophenyl)-2-isopropyl-acetate 
• 223905-29-1 N-[(S)-4-chloro-α-(1-methylethyl)benzeneacetyl]4-nitro-L-phenylalanine 
• 956498-38-7 α-cyano-3-phenoxybenzyl S-(+)-2-(4-chlorophenyl)isovalerate 

Relevant articles and documents

Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase

A series of substituted acyl(thio)urea and 2H-1,2,4-thiadiazolo [2,3-a] pyrimidine derivatives were prepared and both of their cell culture and enzymatic activity toward influenza virus were tested. Their in vitro neuraminidase inhibitory activities were in good agreement with the corresponding activities in cultured cells and they were evaluated as potent neuraminidase inhibitors. Of the analogues that demonstrated IC50s 0.1 μM, 16 and 60 were further investigated as candidates with the most potential for future development. The molecular docking work of the representative compound was described to provide more insight into their mechanism of action and further rationalize the observations of this new series herein, which represents a novel class of highly potent and selective inhibitors of influenza virus.

A novel class of potent influenza virus inhibitors: Polysubstituted acylthiourea and its fused heterocycle derivatives

A series of polysubstituted and fused heterocycle derivatives of acylthiourea was prepared and the biological activity against influenza virus was evaluated. Of the analogues that demonstrated IC50s 0.1 μM, acylthiourea derivatives 16 and 50 were further investigated as candidates with the most potential for future development. The SAR of these compounds are discussed and they represent a novel class of highly potent and selective inhibitors of influenza virus.

An enzyme-linked immunosorbent assay for the detection of esfenvalerate metabolites in human urine

The pyrethroids are one of the most heavily used insecticide classes in the world. Sensitive and rapid analytical techniques are needed for assessments of human exposure to these compounds. Highly sensitive and selective ELISAs for glycine conjugates of e