6625-15-6Relevant articles and documents
Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth
Desai, Janish,Wang, Yang,Wang, Ke,Malwal, Satish R.,Oldfield, Eric
, p. 2205 - 2215 (2016/10/22)
We synthesized potential inhibitors of farnesyl diphosphate synthase (FPPS), undecaprenyl diphosphate synthase (UPPS), or undecaprenyl diphosphate phosphatase (UPPP), and tested them in bacterial cell growth and enzyme inhibition assays. The most active compounds were found to be bisphosphonates with electron-withdrawing aryl-alkyl side chains which inhibited the growth of Gram-negative bacteria (Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa) at ~1–4 μg mL?1levels. They were found to be potent inhibitors of FPPS; cell growth was partially “rescued” by the addition of farnesol or overexpression of FPPS, and there was synergistic activity with known isoprenoid biosynthesis pathway inhibitors. Lipophilic hydroxyalkyl phosphonic acids inhibited UPPS and UPPP at micromolar levels; they were active (~2–6 μg mL?1) against Gram-positive but not Gram-negative organisms, and again exhibited synergistic activity with cell wall biosynthesis inhibitors, but only indifferent effects with other inhibitors. The results are of interest because they describe novel inhibitors of FPPS, UPPS, and UPPP with cell growth inhibitory activities as low as ~1–2 μg mL?1.
Synthesis, structure, and catalytic activity of novel trinuclear rare-earth metal amido complexes incorporating μ-η5:η1 bonding indolyl and μ3-oxo groups
Yang, Song,Zhu, Xiancui,Zhou, Shuangliu,Wang, Shaowu,Feng, Zhijun,Wei, Yun,Miao, Hui,Guo, Liping,Wang, Fenhua,Zhang, Guangchao,Gu, Xiaoxia,Mu, Xiaolong
supporting information, p. 2521 - 2533 (2014/02/14)
The reactions of different pyrrolyl-functionalized indoles with rare-earth metal(iii) amides [(Me3Si)2N]3RE III(μ-Cl)Li(THF)3 (RE = Yb, Er, Dy, Eu, Y) produced different kinds of rare-earth metal amid
Rare-earth metal amido complexes supported by bridged bis(β- diketiminato) ligand as efficient catalysts for hydrophosphonylation of aldehydes and ketones
Miao, Hui,Zhou, Shuang Liu,Wang, Shao Wu,Zhang, Li Jun,Wei, Yun,Yang, Song,Wang, Fen Hua,Chen, Zheng,Chen, Yue,Yuan, Qing Bing
, p. 329 - 336 (2013/07/26)
A series of rare-earth metal amides supported by a cyclohexyl-linked bis(β-diketiminato) ligand were synthesized, and their catalytic activities for hydrophosphonylation of aldehydes and ketones were developed. Reaction of [(Me3Si)2N