66251-88-5

Upstream product

• 66251-86-3 (2,2-dimethyl-propylidene)-methyl-amine oxide 
• 66251-87-4 (3-tert-butyl-2-methyl-[1,2]oxazetidin-4-ylidene)-cyclohexyl-amine 

Relevant academic research and scientific papers

Synthesis of α-ketoamides by a molecular-sieves-promoted formal oxidative coupling of aliphatic aldehydes with isocyanides

(Chemical Equation Presented) A twist in the Ugi four-component reaction: The reaction of an aldehyde, an isocyanide, N-methylhydroxylamine, and acetic acid in the presence of 4-A molecular sieves afforded α-ketoamides in moderate to good yields (see scheme). In contrast, 3-A molecular sieves did not promote the desired multicomponent reaction. R1 = alkyl; R2 = alkyl, aryl.