66256-32-4 Usage
Uses
Used in Pharmaceutical Research:
PHENYLTHIOHYDANTOIN ALPHA-AMINOBUTYRIC ACID is utilized as a research compound for exploring its potential therapeutic applications. Given its structural relation to GABA, it is of interest for the development of treatments targeting disorders associated with GABAergic dysfunction.
Used in Neurological Disorders Treatment:
In the field of neurology, PHENYLTHIOHYDANTOIN ALPHA-AMINOBUTYRIC ACID is considered for its potential use as a therapeutic agent for conditions such as epilepsy, anxiety, and insomnia. Its enhanced pharmacological properties may offer improved management of these disorders by modulating the inhibitory effects of GABA in the central nervous system.
Further studies are necessary to delineate the pharmacological profile and safety of PHENYLTHIOHYDANTOIN ALPHA-AMINOBUTYRIC ACID, ensuring its viability as a pharmaceutical agent for the aforementioned applications.
Check Digit Verification of cas no
The CAS Registry Mumber 66256-32-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,2,5 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66256-32:
(7*6)+(6*6)+(5*2)+(4*5)+(3*6)+(2*3)+(1*2)=134
134 % 10 = 4
So 66256-32-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2OS/c1-2-9-10(14)13(11(15)12-9)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15)
66256-32-4Relevant academic research and scientific papers
Asymmetric Synthesis of Adjacent Tri- and Tetrasubstituted Carbon Stereocenters: Organocatalytic Aldol Reaction of an Hydantoin Surrogate with Azaarene 2-Carbaldehydes
Izquierdo, June,Demurget, Noémie,Landa, Aitor,Brinck, Tore,Mercero, Jose M.,Dinér, Peter,Oiarbide, Mikel,Palomo, Claudio
supporting information, p. 12431 - 12438 (2019/09/17)
A bifunctional amine/squaramide catalyst promoted direct aldol addition of an hydantoin surrogate to pyridine 2-carbaldehyde N-oxides to afford adducts bearing two vicinal tertiary/quaternary carbons in high diastereo- and enantioselectivity (d.r. up to >20:1; ee up to 98 %) is reported. Acid hydrolysis of adducts followed by reduction of the N-oxide group yields enantiopure carbinol-tethered quaternary hydantoin-azaarene conjugates with densely functionalized skeletons. DFT studies of the potential energy surface (B3LYP/6–31+G(d)+CPCM (dichloromethane)) of the reaction correlate the activity of different catalysts and support an intramolecular hydrogen-bond-assisted activation of the squaramide moiety in the transition state of the catalytic reaction.
