66267-69-4

Basic information

• Product Name: 3-phenylpropyl 2-hydroxy-2-phenylacetate
• Synonyms: 3-phenylpropyl 2-hydroxy-2-phenylacetate
• CAS NO: 66267-69-4
• Molecular Weight: 270.328
• Mol File: 66267-69-4.mol

Chemical Properties

• CAS DataBase Reference: 3-phenylpropyl 2-hydroxy-2-phenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylpropyl 2-hydroxy-2-phenylacetate(66267-69-4)
• EPA Substance Registry System: 3-phenylpropyl 2-hydroxy-2-phenylacetate(66267-69-4)

Safety Data

• Hazardous Substances Data: 66267-69-4(Hazardous Substances Data)

Upstream product

• 122-97-4 3-Phenyl-1-propanol 
• 611-71-2 MANDELIC ACID 

Relevant articles and documents

Zirconocene-catalyzed direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1:1 ratio under solvent-free conditions

A highly efficient way for the direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1:1 ratio using a zirconocene complex (1, 1 mol%), a strong Lewis acid of good water tolerance, as a catalyst under solvent-free conditions has been developed. A wide range of acid and alcohol (esters) substrates undergo (trans)esterification to produce carboxylic ester motifs in moderate to good or excellent yields with good functional tolerance, such as that towards C-Br as well as CC and CC bonds. And complex 1 can be recycled six times without showing a significant decline in catalytic efficiency. It was demonstrated that cyclandelate, which is used to treat high blood pressure as well as heart and blood-vessel diseases, can be directly synthesized on a gram scale with 81% yield (6.70 g) using complex 1.

Method for selectively catalytically synthesizing mandelate ester compound from metallocene complex

The invention discloses a method for selectively catalytically synthesizing a mandelate ester compound from a metallocene complex. According to the method, a perfluoroalkane (aromatic) metallocene complex is used as a catalyst; mandelic acid, derivatives thereof and alcohol are used as main raw materials, wherein benzyl hydroxyls in mandelic acid and a derivative II thereof do not have esterification reaction with carboxy groups of mandelic acid but carboxy groups of mandelic acid and the derivative II thereof have esterification reaction with carboxy groups of alcohol III; the materials highly selectively react in the presence of an organic solvent or without a solvent, so that the mandelate ester compound in higher yield can be acquired. The method has the advantages of lower cost, high yield, simple and convenient operation and no pollution and has potential industrial application prospect. The method can be a low-cost and green method for preparing the mandelate ester compound.