66270-36-8

Basic information

• Product Name: 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL CHLOROFORMATE
• Synonyms: TCBOC-CHLORIDE;2,2,2-TRICHLORO-1,1-DIMETHYLETHYL CHLOROFORMATE;BETA,BETA,BETA-TRICHLORO-TERT-BUTOXYCARBONYL CHLORIDE;BETA,BETA,BETA-TRICHLORO-TERT-BUTYL CHLOROFORMATE;Carbonochloridic acid, 2,2,2-trichloro-1,1-dimethylethyl ester;β,β,β-trichloro-tert-butoxycarbonyl chloride;β,β,β-trichloro-tert-butyl chloroformate;TCBoc-chloride, β,β,β-Trichloro-tert-butoxycarbonyl chloride
• CAS NO: 66270-36-8
• Molecular Formula: C₅H₆Cl₄O₂
• Molecular Weight: 239.91
• EINECS: 266-293-4
• Product Categories: CHLOROFORMATES
• Mol File: 66270-36-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 28-30 °C(lit.)
• Boiling Point: 83-84 °C14 mm Hg(lit.)
• Flash Point: 86.1°C
• Appearance: /
• Density: 1.4953 (estimate)
• Vapor Pressure: 0.407mmHg at 25°C
• Refractive Index: 1.49
• Storage Temp.: 2-8°C
• Solubility: ethanol: soluble10%, clear, colorless
• BRN: 1935464
• CAS DataBase Reference: 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL CHLOROFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL CHLOROFORMATE(66270-36-8)
• EPA Substance Registry System: 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL CHLOROFORMATE(66270-36-8)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2928 6.1/PG 2
• WGK Germany: 3
• F: 4.5-10-19-21
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 66270-36-8(Hazardous Substances Data)

Usage

General Description

The solvolysis rate constants of 2,2,2-trichloro-1,1-dimethylethyl chloroformate in binary and pure solvents was studied.

InChI:InChI=1/C5H6Cl4O2/c1-4(2,5(7,8)9)11-3(6)10/h1-2H3

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 57-15-8 1,1,1-trichloro-2-methyl-2-propanol 
• 86964-74-1 3-((2R,3R,4R,5R)-3,4-Diacetoxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carboxylic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester 
• 75-44-5 phosgene 

Downstream Products

• 100167-06-4 TCBOC-Phe-OH 
• 114491-96-2 N¹-(tert-butoxycarbonyl)-N⁴-benzyl-N⁹-(2,2,2-trichloro-tert-butoxycarbonyl)-N¹²-(trifluoroacetyl)spermine 
• 308240-95-1 (3R,5S)-5-{2-[(S)-2-(4-Methoxy-benzyloxy)-3-triisopropylsilanyloxy-propyl]-thiazol-4-yl}-3-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-hexanoic acid (E)-(S)-4-iodo-1,3-dimethyl-but-3-enyl ester 
• 216013-55-7 3-benzyloxy-(S)-2-[(R)-3-nonanoyloxytetradecanoylamino]propyl 2-deoxy-4-O-diphenylphosphono-3-O-[(R)-3-nonanoyloxytetradecanoyl]-6-O-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside 
• 216013-62-6 3-benzyloxy-(S)-2-[(R)-3-heptanoyloxytetradecanoylamino]propyl 2-deoxy-4-O-diphenylphosphono-3-O-[(R)-3-heptanoyloxytetradecanoyl]-6-O-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside 
• 216013-70-6 4-benzyloxy-(S)-3-[(R)-3-decanoyloxytetradecanoyl]butyl 2-deoxy-4-O-diphenylphosphono-3-O-[(R)-3-decanoyloxytetradecanoyl]-6-O-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside 
• 216013-79-5 4-benzyloxy-(S)-2-[(R)-3-decanoyloxytetradecanoyl]butyl 2-deoxy-4-O-diphenylphosphono-3-O-[(R)-3-decanoyloxytetradecanoyl]-6-O-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside 
• 216013-91-1 2-(trimethylsilyl)ethyl 2-deoxy-4-O-diphenylphosphono-3-O-[(R)-3-dodecanoyloxytetradecanoyl]-6-O-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside 
• 216014-00-5 2-(trimethylsilyl)ethyl 2-deoxy-4-O-diphenylphosphono-3-O-[(R)-3-undecanoyloxytetradecanoyl]-6-O-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside 
• 216014-09-4 2-(trimethylsilyl)ethyl 2-deoxy-4-O-diphenylphosphono-3-O-[(R)-3-decanoyloxytetradecanoyl]-6-O-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside 
• 216014-24-3 2-(trimethylsilyl)ethyl 2-deoxy-4-O-diphenylphosphono-3-O-[(R)-3-nonanoyloxytetradecanoyl]-6-O-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside 
• 216014-32-3 2-(trimethylsilyl)ethyl 2-deoxy-4-O-diphenylphosphono-3-O-[(R)-3-octanoyloxytetradecanoyl]-6-O-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside 
• 216014-40-3 2-(trimethylsilyl)ethyl 2-deoxy-4-O-diphenylphosphono-3-O-[(R)-3-heptanoyloxytetradecanoyl]-6-O-(2,2,2-trichloro-1,1-dimethylethoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside 
• 1392437-86-3 butyl (2R)-2-{(2,2,2-trichloro-1,1-dimethylethoxy)carbonyl[(1S)-(1-phenylethyl)]amino}pent-4-enoate 

Relevant articles and documents

Versatile Cp*Co(III)(LX) Catalyst System for Selective Intramolecular C-H Amidation Reactions

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