66277-20-1Relevant academic research and scientific papers
Benzylisoquinoline alkaloids from Gnetum parvifolium
Xu, Qun,Lin, Mao
, p. 1025 - 1027 (1999)
The investigation of the chemical constituents from the lianas of Gnetum parvifolium resulted in the isolation of three new benzylisoquinoline alkaloids, (±)-N-methylhigenamine (1), (-)-N-methylhigenamine N-oxide (2), and (±)-8-(p-hydroxybenzyl)-2,3,10,11-tetrahydroxyprotoberberine (3), together with two known alkaloids, higenamine and trigonelline. The structures of 1-3 were determined by chemical methods and spectral analysis including 2D NMR and NOE studies.
Ability of higenamine and related compounds to enhance glucose uptake in L6 cells
Kato, Eisuke,Kimura, Shunsuke,Kawabata, Jun
, p. 6412 - 6416 (2017)
β2-Adrenergic receptor (β2AR) agonists are employed as bronchodilators to treat pulmonary disorders, but are attracting attention for their modulation of glucose handling and energy expenditure. Higenamine is a tetrahydroisoquinoline present in several plant species and has β2AR agonist activity, but the involvement of each functional groups in β2AR agonist activity and its effectiveness compared with endogenous catecholamines (dopamine, epinephrine, and norepinephrine) has rarely been studied. Glucose uptake of muscle cells are known to be induced through β2AR activation. Here, the ability to enhance glucose uptake of higenamine was compared with that of several methylated derivatives of higenamine or endogenous catecholamines. We found that: (i) the functional groups of higenamine except for the 4′-hydroxy group are required to enhance glucose uptake; (ii) higenamine shows a comparable ability to enhance glucose uptake with that of epinephrine and norepinephrine; (iii) the S-isomer shows a greater ability to enhance glucose uptake compared with that of the R-isomer.
Isolation and preparation of 3H-tetrandrine
Huang,Wang,Lu
, p. 899 - 903 (2007/10/02)
Tetrandrine is a biabenzytehahydroisoquinoline alkaloid. Its structure is vary complex and the preparation of labeled derivatives is difficult. We have prepared 3H-tatrandrine using the tritium gas exposure method. This method produces many fragments which make isolation and purification of small quantities difficult. We investigated these fragments of unlabeled d-tetrandrine and found almost all contain one to several hydroxide groups. Using this information, we designed a two-step paper chromatography method for isolation and purification of 3H-Tetrandrine. This method involves the application of a pH 4.7 Na2HPO4-citric acid buffer to the paper to block the migration of hydroxide group fragments of tetrandrine. 3H-tetrandrine was successfully with a radiochemical purity of 90%.
