66279-46-7

Usage

Uses

Used in Scientific Research and Development:
Carbamimidothioic acid, (2,6-dichlorophenyl)methyl ester,monohydrochloride is used as a research chemical for [application reason], which is primarily due to its complex structure and the presence of various functional groups. Its applications in this field are mainly for [application reason], such as studying its chemical properties, potential interactions with other compounds, and possible uses in the synthesis of new materials or pharmaceuticals.
However, it is important to note that specific data regarding its applications, safety measures, and toxicity levels are limited. Therefore, it is crucial to handle and use Carbamimidothioic acid, (2,6-dichlorophenyl)methyl ester,monohydrochloride with caution, adhering to proper safety protocols and guidelines to minimize potential risks.

Upstream product

• 2014-83-7 1,3-Dichloro-2-chloromethyl-benzene 
• 17356-08-0 thiourea 

Downstream Products

• 5219-69-2 Bis-(2,6-dichlor-benzyl)-disulfid 
• 1159004-31-5 3-(2,6-dichlorobenzyl)sulfanyl-5,5-dimethyl-4,5-dihydroisoxazole 
• 66279-47-8 2,6-dichlorobenzyl mercaptan 

Relevant academic research and scientific papers

Chiral 3-(benzylsulfinyl)-5,5-dimethyl-4,5-dihydroisoxazole derivatives and 5,5-dimethyl-3-[(1H-pyrazol-4-ylmethyl)sulfinyl]-4,5-dihydroisoxazole derivatives, method for the production thereof, and use of same as herbicides and plant growth regulations

The invention relates to 3-(benzylsulfinyl)-5,5-dimethyl-4,5-dihydroisoxazole derivatives and 5,5-dimethyl-3-[(1H-pyrazol-4-ylmethyl)sulfinyl]-4,5-dihydroisoxazole derivatives of the formula (I) and their salts processes for their preparation and their use as herbicides and plant growth regulators, in particular as herbicides for the selective control of harmful plants in crops of useful plants.

INHIBITION OF CELL PROLIFERATION

The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.