6629-53-4Relevant academic research and scientific papers
A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones
Radi, Marco,Vallerini, Gian Paolo,Petrelli, Alessia,Vincetti, Paolo,Costantino, Gabriele
supporting information, p. 6905 - 6908 (2019/04/10)
A fast, versatile and practical one-pot, two-step microwave-assisted protocol for the direct synthesis of N1-substituted 5,6-ring-fused 2-pyridones has been developed. The present method proved to be effective on a series of commercially available aldehydes, ketones and amines and could be profitably exploited in drug-discovery settings for the rapid identification of biologically relevant hit compounds.
Simple, efficient, and green method for synthesis of trisubstituted electrophilic alkenes using lipase as a biocatalyst
Borse, Bhushan Nanasaheb,Shukla, Sanjeev Ramchandra,Sonawane, Yogesh Ashok
experimental part, p. 412 - 423 (2011/11/12)
A simple and efficient Knoevenagel condensation method for the synthesis of trisubstituted electrophilic alkenes was developed using lipase as a biocatalyst. Knoevenagel condensation was performed using the conventional method and using lipases (Aspergillus oryzae or Rhizopus oryzae) as biocatalysts, and reaction time, reaction temperature, yield, and recyclability were compared. Using a lipase as a biocatalyst eliminated the need for bases such as piperidine and pyridine. A wide range of aromatic aldehydes and ketones readily undergo condensation with active methylene compounds. The workup procedure is also very simple, and yields of the reactions are in the range of 75%to 95%. Both the biocatalysts were effectively recycled four times with no major decrease in the yield of product. The remarkable catalytic activity and reusability of lipase widens its applicability in Knoevenagel condensation with good to excellent yields for synthesis of trisubstituted electrophilic alkenes.Copyright Taylor & Francis Group, LLC.
