663-39-8

Basic information

• Product Name: (3beta,5alpha,6beta)-6-hydroxy-3,5-cycloandrostan-17-one
• CAS NO: 663-39-8
• Molecular Formula: C₁₉H₂₈O₂
• Molecular Weight: 288.4244
• Mol File: 663-39-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 418.6°C at 760 mmHg
• Flash Point: 178.7°C
• Density: 1.17g/cm³
• Vapor Pressure: 9.31E-09mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: (3beta,5alpha,6beta)-6-hydroxy-3,5-cycloandrostan-17-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3beta,5alpha,6beta)-6-hydroxy-3,5-cycloandrostan-17-one(663-39-8)
• EPA Substance Registry System: (3beta,5alpha,6beta)-6-hydroxy-3,5-cycloandrostan-17-one(663-39-8)

Safety Data

• Hazardous Substances Data: 663-39-8(Hazardous Substances Data)

Usage

General Description

(3beta,5alpha,6beta)-6-hydroxy-3,5-cycloandrostan-17-one is a steroidal compound that belongs to the androstane class. It is a naturally occurring metabolite found in the human body and is involved in various biological processes. This chemical is a derivative of androstan-17-one, which is a steroid hormone that plays a key role in the development and maintenance of male characteristics. The hydroxyl group at the 6th position of the molecule contributes to its biological activity and may be involved in its interactions with other molecules in the body. (3beta,5alpha,6beta)-6-hydroxy-3,5-cycloandrostan-17-one may have potential pharmacological and therapeutic applications due to its involvement in hormone regulation and its effects on the human body.

Upstream product

• 53-43-0 dehydroepiandrosterone 
• 381719-75-1 3α,5-cyclo-5α-androstan-6β,17β-diol 
• 2719-96-2 3β-tosyloxyandrost-5-ene-17-one 
• 651-48-9 dehydroepiandrosterone sulfate 

Downstream Products

• 53-43-0 dehydroepiandrosterone 
• 564-33-0 11α-hydroxyandrost-4-ene-3,17-dione 
• 14414-15-4 3α.5-Cyclo-5α-androstan-6β-ol-17-on<16-spiro-1'>cyclohexanol-(2')-on-(4') 
• 361-79-5 3β-fluoro-androst-5-en-17β-ol 
• 897-01-8 (3S,8R,9S,10R,13S,14S)-3-Chloro-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one 
• 2487-48-1 3β,7α-dihydroxyandrost-5-ene-17-one 
• 2487-48-1 5-androsten-3β,7β-diol-17-one 
• 10161-36-1 3β,5α,6β-trihydroxy-5α-androstan-17-one 
• 24357-28-6 6β,14α-dihydroxy-3α,5-cycloandrostan-17-one 
• 94991-86-3 3β,14α-dihydroxy-androst-5-en-17-one 
• 1224-07-3 3α,5-cycloandrost-6-en-17-one 
• 438-20-0 3β-fluoro-5-androsten-17-one 

Relevant articles and documents

Metabolic fate of 3α,5-cycloandrostanes in the endogenous lactonization pathway of Aspergillus tamarii KITA

A series of 3α,5-cycloandrostane analogues with a range of functionality (6α and 6β alcohols and ketone) at carbon 6 were tested in the endogenous lactonization pathway in Aspergillus tamarii KITA. This metabolic route converts progesterone to testololactone in high yield through a four step enzymatic pathway. To date, no studies have looked at the effect of steroids devoid of polar functionality at carbon 3 and their subsequent metabolic fate by fungi which contain Baeyer-Villiger monooxygenases. Incubation of all of the cycloandrostane analogues resulted in lactonization of ring-D irrespective of C-6 stereochemistry or absence of C-3 functionality. Presence of 6β-hydroxy group and the C-17 ketone was required in order for these analogues to undergo hydroxylation at C-15β position. All metabolites were isolated by column chromatography and were identified by 1H, 13C NMR, DEPT analysis and other spectroscopic data.

The Participation of 3,5-Cyclosteroids in Aromatization Reactions

The preparation of 6β,7β-dihydroxy-3α-5-cycloandrostan-17-one and 2β,17β-diacetoxy-6α-hydroxy-3α,5-cycloandrostane and their reaction with hydrobromic acid in acetic acid is described.They both afford the corresponding 4-methylestratriene accompanied by,