6630-58-6

Usage

Uses

Used in Pharmaceutical Industry:
(5Z)-5-(ethoxymethylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one is used as a pharmaceutical compound for its potential therapeutic applications. Its unique structure and properties make it a promising candidate for the development of new drugs, particularly in the areas of infectious diseases and other medical conditions that may benefit from its pharmacological properties.
Used in Organic Synthesis:
In the field of organic chemistry, (5Z)-5-(ethoxymethylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one is used as a building block for the synthesis of more complex organic compounds. Its versatile structure allows for various chemical reactions and modifications, enabling the creation of a wide range of molecules with different properties and applications.
Used in Research and Development:
(5Z)-5-(ethoxymethylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one is also used in research and development for exploring its biological activities and pharmacological properties. Scientists and researchers are interested in understanding how (5Z)-5-(ethoxymethylidene)-3-methyl-2-thioxo-1,3-thiazolidin-4-one interacts with biological systems and how it can be utilized to develop new treatments for various diseases and conditions.

Upstream product

• 4807-55-0 3-Methyl-2-thioxo-thiazolidin-4-on 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 5199-12-2 2-Thioxo-3-methyl-4-oxo-5-piperidinomethylen-thiazolidin 
• 5571-18-6 3-Methyl-5-<2-morpholino-cyclohexen-1-ylmethylen>-rhodanin 
• 5500-54-9 5-[3,3-bis-(4-dimethylamino-phenyl)-allylidene]-3-methyl-2-thioxo-thiazolidin-4-one 
• 46826-07-7 2-(3-methyl-4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-cyclohexane-1,3-dione 
• 5199-04-2 3-Methyl-5-(β-benzoylethyliden)rhodanin 
• 1621417-82-0 5-[5-(4-methoxyphenyl)-3-naphthalen-2-yl-4,5-dihydropyrazol-1-ylmethylene]-3-methyl-2-thioxothiazolidin-4-one 
• 1621417-80-8 5-[5-(4-chlorophenyl)-3-phenyl-4,5-dihydropyrazol-1-ylmethylene]-3-methyl-2-thioxothiazolidin-4-one 
• 1621417-81-9 5-[5-(4-chlorophenyl)-3-naphthalen-2-yl-4,5-dihydropyrazol-1-ylmethylene]-3-methyl-2-thioxothiazolidin-4-one 
• 5199-08-6 2-[2-(1-cyano-2-oxo-2-phenyl-ethylidene)-3-methyl-4-oxo-thiazolidin-5-ylidenemethyl]-3-oxo-butyric acid ethyl ester 
• 73855-56-8 5-aminomethylene-3-methyl-2-thioxo-thiazolidin-4-one 
• 86291-07-8 (3-methyl-4-oxo-2-thioxo-thiazolidin-5-yl)-(4-oxo-3-phenyl-2-thioxo-thiazolidin-5-ylidene)-methane 

Relevant academic research and scientific papers

5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells

The article presents the synthesis of 5-ene-4-thiazolidinone derivatives with pyrazole core linked by enamine group. The structure and purity of compounds were confirmed by analytical and spectral data including X-ray analysis. Target compounds were scree

Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity

A series of novel 4-thiazolidinone-pyrazoline conjugates have been synthesized and tested for anti-Trypanosoma brucei activity. Screening data allowed us to identify five thiazolidinone-pyrazoline hybrids, which possess promising trypanocidal activity, with IC50 ≤ 1.2 μM. The highest active thiazolidinone-pyrazoline conjugates 3c and 6b (IC values of 0.6 μM and 0.7 μM, respectively) were 6-times more potent antitrypanosomal agents than nifurtimox. In addition, these compounds, as well as 6d and 6e had selectivity index higher than 50, and were more selective than nifurtimox. SAR study included substituent variations at the pyrazoline moiety, modifications of N3 position of the thiazolidinone portion, elongation of the linker between the heterocycles, as well as rhodanine-isorhodanine isomerism. It was also shown that methyl or aryl substitution at the thiazolidinone N3-position is crucial for trypanocidal activity.