663155-50-8Relevant academic research and scientific papers
Synthesis of spiro[4.5]decane and bicyclo[4.3.0]nonane ring systems by self-cyclization of (Z)- and (E)-2-(trimethylsilylmethyl)pentadienal derivative
Kuroda, Chiaki,Honda, Shigenobu,Nagura, Yuki,Koshio, Hiroyuki,Shibue, Taku,Takeshita, Tokio
, p. 319 - 331 (2007/10/03)
The two title carbon frameworks were synthesized utilizing a new type of iron-induced cyclization reaction of 2-(trimethylsilylmethyl)pentadienal. 2-Methylspiro[4.5]dec-2-en-1-one was obtained from (Z)- and (E)-4- cyclohexylidene-2-(trimethylsilylmethyl)but-2-enal. It was found that the (Z)-substrate isomerized to (E)-intermediate followed by cyclization to afford the initial product, 2-methylenespiro[4.5]dec-3-en-1-ol, which was isomerized to the above product. The cyclization of 4-(4-alkyl)cyclohexylidene-2- (trimethylsilylmethyl)but-2-enal proceeded stereoselectively. While, (E)-3-(cyclohex-1-en-1-yl)-2-(trimethylsilylmethyl)prop-2-en-1-al cyclized immediately affording 8-methylenebicyclo[4.3.0]non-9-en-7-ol. The corresponding (Z)-isomer gave several cyclization products as a complex mixture.
Synthesis and structure of ansa-metallocene complexes (M=ZrCl2, TiCl2, YCl, and LuCl) containing the bis(2-methyl-4,5,6,7-tetrahydroinden-yl)dimethylsilane ligand
Halterman, Ronald L.,Schumann, Herbert,Dübner, Frank
, p. 12 - 19 (2007/10/03)
The three step synthesis of 2-methyl-4,5,6,7-tetrahydro-1H-indene from cyclohexyl methacrylate is described [(a) PPA cyclization; (b) LiAlH4 reduction; (c) HCl dehydration]. This annelated trisubstituted cyclopentadiene was bridged selectively to form ethylene- or dimethylsilyl-bridged bis(2-methyl-4,5,6,7-tetrahydro-1H-inden-1-yl) ligands. Metal complexes (M=ZrCl2, TiCl2, YCl, and LuCl) of the bis(2-methyl-4,5,6,7-tetrahydroinden-1-yl)dimethylsilane ligand were formed as meso/dl stereoisomeric mixtures in ratios from 1:1 to 2:1 dl:meso.
