663190-26-9Relevant academic research and scientific papers
X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues
Lee, Kang Man,Choi, Won Jun,Lee, Yoonji,Lee, Hyun Joo,Zhao, Long Xuan,Lee, Hyuk Woo,Park, Jae Gyu,Kim, Hea Ok,Hwang, Kwang Yeon,Heo, Yong-Seok,Choi, Sun,Jeong, Lak Shin
supporting information; experimental part, p. 930 - 938 (2011/04/24)
The X-ray crystal structure of human S-adenosylhomocysteine (AdoHcy) hydrolase was first determined as a tetrameric form bound with the novel mechanism-based inhibitor fluoroneplanocin A (4b). The crystallized enzyme complex showed the closed conformation
AHCY HYDROLASE INHIBITORS FOR TREATMENT OF HYPER HOMOCYSTEINEMIA
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Page/Page column 19; 20, (2011/07/08)
The present invention is directed to AHCY inhibitors of formula (I): which are useful in the treatment of diseases characterized by high homocysteine levels, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases characterized by high homocysteine levels.
Truncated fluorocyclopentenyl pyrimidines as S-adenosylhomocysteine hydrolase inhibitors
Park, Yeon Hee,Choi, Won Jun,Tipnis, Amol S.,Lee, Kang Man,Jeong, Lak Shin
experimental part, p. 601 - 613 (2010/10/01)
On the basis of inhibitory activity of truncated cyclopentenyl cytosine against S-adenosylhomocysteine hydrolase (SAH), its fluorocyclopentenyl pyrimidine derivatives were efficiently synthesized from D-ribose via electrophilic fluorination as a key step.
Synthesis of halogenated 9-(dihydroxycyclopent-4′-enyl) adenines and their inhibitory activities against S-Adenosylhomocysteine hydrolase
Jeong, Lak Shin,Park, Jae Gyu,Choi, Won Jun,Moon, Hyung Ryong,Lee, Kang Man,Kim, Hea Ok,Kim, Hee-Doo,Chun, Moon Woo,Park, Hea-Young,Kim, Kilhyoun,Sheen, Yhun Y.
, p. 919 - 921 (2007/10/03)
Novel halovinyl analogues of neplanocin A without 4′-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.
