6632-65-1

Basic information

• Product Name: 1-FURFURYL-3-PHENYL-2-THIOUREA
• Synonyms: 1-FURFURYL-3-PHENYL-2-THIOUREA;1-(furan-2-ylmethyl)-3-phenylthiourea
• CAS NO: 6632-65-1
• Molecular Formula: C₁₂H₁₂N₂OS
• Molecular Weight: 232.30148
• Mol File: 6632-65-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 355.1°Cat760mmHg
• Flash Point: 168.5°C
• Appearance: /
• Density: 1.271g/cm³
• CAS DataBase Reference: 1-FURFURYL-3-PHENYL-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-FURFURYL-3-PHENYL-2-THIOUREA(6632-65-1)
• EPA Substance Registry System: 1-FURFURYL-3-PHENYL-2-THIOUREA(6632-65-1)

Safety Data

• Hazardous Substances Data: 6632-65-1(Hazardous Substances Data)

Usage

General Description

1-Furfuryl-3-phenyl-2-thiourea, also known as S-phenyl-furfurylthiourea, is an organic compound with the chemical formula C14H14N2OS. It is a white, crystalline solid that is soluble in organic solvents. 1-FURFURYL-3-PHENYL-2-THIOUREA is widely used as a corrosion inhibitor in the rubber and rubber processing industries, as well as in the oil drilling and extraction sectors. It can also be employed as a photoinitiator in the polymerization of certain resins and as a vulcanization accelerator for rubber. Additionally, 1-Furfuryl-3-phenyl-2-thiourea has been studied for its potential biological activities, including its role as an inhibitor of crystallization and as an anti-diabetic agent.

Upstream product

• 62-53-3 aniline 
• 617-89-0 furan-2-ylmethanamine 
• 2423-29-2 N-phenyl-O-phenylthiocarbamate 
• 35753-90-3 phenyl-thiocarbamoyl chloride 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 608490-27-3 C₂₇H₂₁N₃O₂S 
• 1180032-19-2 C₂₂H₁₉N₃O₂S*ClH 
• 608490-29-5 C₂₆H₂₁N₃O₃S 
• 1017523-66-8 C₂₈H₂₃N₃O₂S 
• 1141433-47-7 C₂₃H₂₁N₃O₂S 
• 1011794-26-5 3-(furfuryl)-4-methyl-2-phenylimino-3H-thiazole 

Relevant articles and documents

Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids

In continuation of our previous work, a series of furan-thiazolidinone hybrids was prepared by Knoevenagel condensation of 3-(furan-2-ylmethyl)-2-(phenylimino)-1, 3-thiazolidin-4-one with different aryl aldehydes in presence of strong base. Some members o

Synthesis of metronidazole based thiazolidinone analogs as promising antiamoebic agents

Metronidazole and its derivatives are widely used for the treatment of amoebiasis. However, metronidazole is considered as the standard drug but it has many side effects. The present study describes the synthesis of a series of metronidazole based thiazolidinone analogs via Knoevenagel condensation of 4-[2-(2-methyl-5-nitro-1H-imidazole-1-yl)ethoxy]benzaldehyde 1 with various thiazolidinone derivatives 2–14 to get the new scaffold (15–27) having better activity and lesser toxicity. Six compounds have shown better efficacy and lesser cytotoxicity than the standard drug metronidazole towards HM1: IMSS strain of Entamoeba histolytica. These compounds may combat the problem of drug resistance and might be effective in identifying potential alternatives for future drug discovery against EhOASS.

Synthesis and in vitro urease inhibitory activity of N,N′- disubstituted thioureas

Thiourea derivatives (1-38) were synthesized and evaluated for their urease inhibition potential. The synthetic compounds showed a varying degree of in vitro urease inhibition with IC50 values 5.53 ± 0.02-91.50 ± 0.08 μM, most of which are superior to the standard thiourea (IC50 = 21.00 ± 0.11 μM). In order to ensure the mode of inhibition of these compounds, the kinetic study of the most active compounds has been carried out. Most of these inhibitors were found to be mixed-type of inhibitors, except compounds 13 and 30 which were competitive, while compound 19 was identified as non-competitive inhibitor with Ki values between 8.6 and 19.29 μM.