66325-67-5Relevant academic research and scientific papers
Composition comprising a phenylalanine-chloroquine derivative as an active ingredient for preventing and treating malaria infection
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Paragraph 0091; 0093; 0156; 0165-0166; 0201-0202, (2018/07/28)
The present invention relates to a composition, comprising a phenylalanine-chloroquine derivative compound, represented by a general formula (I), with a novel structure or a pharmacologically acceptable salt as an active ingredient, for treating and preventing malaria. As a result of identification of anti-malaria activity through a search (experiment example 1) for an anti-malaria effect in vitro by using a strain of Plasmodium falciparum and an animal test (experiment example 2) using a mouse infected from malaria with respect to phenylalanine-chloroquine derivative compounds with novel structures, the novel compounds have been identified to have excellent anti-malaria activity. Accordingly, an anti-malaria agent comprising a phenylalanine-chloroquine derivative compound with a novel structure or a pharmacologically acceptable salt as an active ingredient is provided.COPYRIGHT KIPO 2018
Microwave-enhanced synthesis of phosphonoacetamides
Gruber, Nadia,Mollo, Mara C.,Zani, Mariana,Orelli, Liliana R.
experimental part, p. 738 - 746 (2011/12/15)
An efficient microwave protocol is described for the Michaelis-Arbuzov synthesis of secondary and tertiary N-aryl (and alkyl) (diethylphosphono) acetamides 1, by reaction of chloro- and bromoacetamides with triethyl phosphite in the presence of catalytic
NMR spectroscopic study of some novel N,N-disubstituted phosphonoacetamides
Orelli, Liliana R.,Gruber, Nadia
experimental part, p. 215 - 218 (2009/08/15)
The complete 1H and 13C NMR assignments of a series of tertiary phosphonoacetamides (1) with different N-substitution patterns are reported. N,N-Dialkyl derivatives show two sets of signals due to hindered rotation of the (O)C{single bond}N bond, which originate E/Z diastereoisomers for unsymmetrically N,N-disubstituted derivatives. Complete assignment of the 1H NMR resonances of both rotamers was made on the basis of the magnitude of the diamagnetic shifts (Δδ) experienced by the signals on changing the solvent from CDCl3 to C6D6, and confirmed in the corresponding NOESY spectra. Differential assignment of the 13C NMR signals was performed by HSQC experiments. N-Alkyl-N-phenyl phosphonoacetamides show a unique set of signals corresponding to the E isomers as disclosed by NOESY experiments.
