66333-58-2Relevant academic research and scientific papers
INTRAMOLECULAR METAL CATALYZED KHARASCH CYCLIZATION OF OLEFINIC α-HALO ESTERS AND ACIDS
Lee, Gary M.,Weinreb, Parvez,Weinreb, Steven M,
, p. 4671 - 4678 (2007/10/02)
Functionalized carbocyclyc compounds are produced by intramolecular Kharasch radical cyclization reactions catalyzed by various transition metal complexes.Several unsaturated mono-α-haloesters and acids can be efficiently transformed to γ-halocarboxyl and γ-lactone carbocycles via exo closure of a 5-hexenyl type radical intermediate.The cyclization methodology is useful for synthesis of both fused and bridged carbocycles.
