66333-88-8

Basic information

• Product Name: OXAZOLE, 5-METHYL-
• Synonyms: OXAZOLE, 5-METHYL-
• CAS NO: 66333-88-8
• Molecular Formula: C₄H₅NO
• Molecular Weight: 83.0886
• Mol File: 66333-88-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 88 °C at 760 mmHg
• Flash Point: 20.5 °C
• Appearance: /
• Density: 1.016 g/cm³
• Storage Temp.: 2-8°C
• PKA: 1.70±0.10(Predicted)
• CAS DataBase Reference: OXAZOLE, 5-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: OXAZOLE, 5-METHYL-(66333-88-8)
• EPA Substance Registry System: OXAZOLE, 5-METHYL-(66333-88-8)

Safety Data

• Hazardous Substances Data: 66333-88-8(Hazardous Substances Data)

Usage

General Description

5-Methyl oxazole is an organic compound belonging to the oxazole class of heterocyclic aromatic compounds. It is a five-membered ring with oxygen and nitrogen atoms at adjacent positions. The 5-methyl oxazole is a colorless liquid with a fruity odor and is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also a common building block in the preparation of various biologically active molecules and is used as a solvent in some chemical reactions. With its versatile chemical properties, 5-methyl oxazole has applications in a wide range of industrial and research processes.

Upstream product

• 15625-88-4 1-acetyl-1H-[1,2,4]triazole 
• 103879-58-9 5-methyloxazole-4-carboxylic acid 
• 74616-91-4 5-Methyl-4-oxazolcarbonsaeure-Natriumsalz 

Downstream Products

• 129053-67-4 2-bromo-5-methyl-oxazole 

Relevant articles and documents

Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki–Miyaura Reactions of Bromooxazole Building Blocks

An approach to synthesis of 2-, 4-, and 5-bromooxazoles is described. The method was optimized, and its scope was extended to all three isomeric parents, as well as various alkyl- and aryl-substituted bromooxazoles. It was found that direct regiocontrolled lithiation followed by reaction with electrophilic bromine source was common for all substrates and led exclusively to the target substituted 2-, 4- and 5-bromooxazoles on multigram scale. The utility of the multipurpose building blocks obtained in this work was demonstrated in the Suzuki–Miyaura cross-coupling reaction under parallel synthesis conditions.

PYROLYSE-ECLAIR SOUS VIDE DE 1,2,4-TRIAZOLIDES = UNE ETUDE PAR SPECTROMETRIE DE MASSE EN TANDEM

A real-time analysis of the flash-vacuum pyrolysis products of some 1,2,4-triazolides has been performed by tandem mass spectrometry.Beside decay products, ketenes and the parent 1,2,4-triazole, 1-acyltriazoles give rise to 5-alkyloxazoles and nitrogen.This ring transformation reaction implies a sigmatropic shift of the acyl group from nitrogen to carbon, loss of nitrogen and cyclisation of the biradical intermediate. 5-aryloxazoles are similarly obtained from 1-aroyltriazoles.

CONVERSION OF TRIAZOLIDES INTO OXAZOLES BY FLASH-VACUUM PYROLYSIS.

Flash-vacuum pyrolysis of azolides of 1,2,4-triazole affords 5-monosubstituted oxazoles.