6635-39-8Relevant academic research and scientific papers
Click chemistry inspired synthesis and bioevaluation of novel triazolyl derivatives of osthol as potent cytotoxic agents
Farooq, Saleem,Shakeel-U-Rehman,Hussain, Aashiq,Hamid, Abid,Qurishi, Mushtaq A.,Koul, Surrinder
, p. 545 - 554 (2015/03/14)
A new series of diverse triazoles linked through the hydroxyl group of lactone ring opened osthol (1) were synthesized using click chemistry approach. All the derivatives were subjected to 3-(4,5-Dimethylthiazol-yl)-diphenyl tetrazoliumbromide (MTT) cytot
Triazolbenzo[d]thiazoles: Efficient synthesis and biological evaluation as neuroprotective agents
Avila, Belem,Roth, Aaron,Streets, Heather,Kurth, Mark J.,Dwyer, Donard S.
, p. 5976 - 5978,3 (2020/08/31)
A number of (1H-1,2,3-triazol-1-yl)benzo[d]thiazoles were synthesized utilizing a versatile Cu-catalyzed azide-alkyne click reaction (CuAAC) on tautomeric benzo[4,5]thiazolo[3,2-d]tetrazole (1) and 2-azidobenzo[d]thiazole (2) starting materials. Moreover, one of the resulting products of this investigation, triazolbenzo[d]thiazole 22, was found to possess significant neuroprotective activity in human neuroblastoma (SH-SY5Y) cells.
Development of benzothiazole 'click-on' fluorogenic dyes
Qi, Jianjun,Tung, Ching-Hsuan
scheme or table, p. 320 - 323 (2011/02/25)
'Click-on' fluorogenic reaction: a non-fluorescent benzothiazole with an electron-deficient alkyne group at 2-position reacts with azide containing molecules could form fluorescent adducts.
On the utility of the azido transfer protocol: Synthesis of 2- And 5-azido N-methylimidazoles, 1,3-thiazoles and N-methylpyrazole and their conversion to triazole - azole bisheteroaryls
Zanirato, Paolo,Cerini, Stefano
, p. 1508 - 1513 (2007/10/03)
The azido transfer procedure of heteroaryllithium and tosyl azide was used to synthesize selected 2- and 5-azidoazoles. This procedure, which is based on the fragmentation of the appropriate lithium triazene salts 1a-7a, successfully afforded 2-azido-N-methylimidazole 1, 2-azido-l,3-thiazole 2, 2-azidobenzo-1.3-thiazole 3, 5-azido-N-methylpyrazole 4, 5-azido-N- methylimidazole 6 [via 2-(trimethylsilyl)-5-azido-N-methylimidazole 5], and 5-azido-l,3-thiazole 7 (via 5-lithio-1,3-thiazole), but attempts to prepare 5-azido-2-(trimethylsilyl)-1,3-thiazole 8 from the corresponding triazene 7a failed, affording only the desilylated azide 7 in poor yield. Azidcs 1-7 underwent 1,3-dipolar cycloaddition when mixed with neat (trimethylsilyl) acetylene, giving 1-heteroaryl-4-trimethylsilyl-1,2.3-triazoles 1b-7b generally in very high yields. The Royal Society of Chemistry 2005.
An easy access to aryl azides from aryl amines under neutral conditions
Das, Jagattaran,Patil, Santoshkumar N.,Awasthi, Riti,Narasimhulu, C. Prasad,Trehan, Sanjay
, p. 1801 - 1806 (2007/10/03)
A variety of substituted aryl amines were transformed into aryl azides using t-BuONO and moist NaN3 in t-BuOH in good to excellent yields. Smooth transformation was observed with anilines, having electron withdrawing and donating groups. Both acid- and base-sensitive groups survived the reaction conditions. Georg Thieme Verlag Stuttgart.
