6636-74-4

Basic information

• Product Name: N,N-Bis(2-chloroethyl)-3-methoxyaniline
• Synonyms: N,N-Bis(2-chloroethyl)-3-methoxyaniline
• CAS NO: 6636-74-4
• Molecular Formula: C₁₁H₁₅Cl₂NO
• Molecular Weight: 248.1489
• Mol File: 6636-74-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 336.1°C at 760 mmHg
• Flash Point: 157°C
• Appearance: /
• Density: 1.197g/cm³
• Vapor Pressure: 0.000115mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: N,N-Bis(2-chloroethyl)-3-methoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Bis(2-chloroethyl)-3-methoxyaniline(6636-74-4)
• EPA Substance Registry System: N,N-Bis(2-chloroethyl)-3-methoxyaniline(6636-74-4)

Safety Data

• Hazardous Substances Data: 6636-74-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H15Cl2NO/c1-15-11-4-2-3-10(9-11)14(7-5-12)8-6-13/h2-4,9H,5-8H2,1H3

Upstream product

• 17126-75-9 3-methoxy-bisaniline 
• 1268821-40-4 N,N-bis(2-(methylsulfonyloxy)ethyl)-3-methoxylaniline 
• 536-90-3 m-Anisidine 

Downstream Products

• 1268821-33-5 4'-(3-methoxyphenyl)spiro[indoline-1,1'-piperazin]-1-ium chloride 
• 857600-15-8 N,N-bis-(2-chloro-ethyl)-3-methoxy-4-nitroso-aniline 

Relevant articles and documents

Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR2R3 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via π-π interaction. Introduction of substituting group on the N4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 μM/kg, sc) and holds promise for development as a mechanically new analgesic drug.