663603-28-9Relevant academic research and scientific papers
Acetal-functionalized RAPTA complexes for conjugation and labeling
Tan, Yu Qian,Dyson, Paul J.,Ang, Wee Han
, p. 5965 - 5971 (2011)
Ruthenium-arene complexes bearing the 1,3,5-triaza-7-phosphatricyclo-[3.3. 1.1]decane ligand, namely, RAPTA compounds, are widely investigated as potential antimetastatic agents for cancer therapy. Although much evidence points toward covalent binding wit
A New Class of "Tethered" Ruthenium(II) Catalyst for Asymmetric Transfer Hydrogenation Reactions
Hannedouche, Jerome,Clarkson, Guy J.,Wills, Martin
, p. 986 - 987 (2007/10/03)
Ruthenium dimer 4 is converted directly to monomeric asymmetric transfer hydrogenation catalyst 2 under the conditions employed for ketone reduction. Using 0.25 mol % of either 4 or 0.5 mol % of 2 in formic acid/triethylamine, it is possible to achieve ketone reduction in quantitative conversion and with ee's as high as 98%. Complex 2 is a robust "single-reagent" catalyst which offers significant scope for modification toward specific substrates. The synthesis and applications of an analogous complex derived from (1R,2S)-norephedrine are also described. Copyright
