66367-67-7

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrazol-3-aMine, 4-Methyl-5-phenylis used as a building block for the synthesis of pharmaceuticals due to its potential pharmacological activities. Its anti-inflammatory and antipyretic properties make it a valuable component in the development of medications aimed at treating inflammation and fever.
Used in Agrochemical Industry:
In the agrochemical sector, 1H-Pyrazol-3-aMine, 4-Methyl-5-phenylis utilized as a precursor in the creation of agrochemicals, contributing to the development of products that can enhance crop protection and yield.
Used in Organic Synthesis:
1H-Pyrazol-3-aMine, 4-Methyl-5-phenylis employed as a versatile intermediate in organic synthesis, facilitating the production of a wide range of organic compounds beyond pharmaceuticals and agrochemicals.
Used in Metal-Catalyzed Reactions:
As a ligand in metal-catalyzed reactions, 1H-Pyrazol-3-aMine, 4-Methyl-5-phenylplays a crucial role in various chemical processes, enhancing the efficiency and selectivity of these reactions in the synthesis of complex organic molecules.

InChI:InChI=1/C10H11N3/c1-7-9(12-13-10(7)11)8-5-3-2-4-6-8/h2-6H,1H3,(H3,11,12,13)

Upstream product

• 7391-29-9 2-methyl-3-oxo-3-phenylpropanenitrile 
• 25388-07-2 5-hydrazino-4-methyl-3-phenyl-isoxazole 
• 21555-07-7 3-(tert-butylimino)-2-methyl-1-phenylprop-2-en-1-one 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 6084-17-9 2-chloro-1-phenylpropan-1-one 

Downstream Products

• 109504-99-6 (3,5-dimethyl-7-oxo-2-phenyl-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-6-yl)-acetic acid ethyl ester 
• 109013-25-4 5-Amino-4-methyl-N,3-diphenyl-1H-pyrazol-1-carboxamid 
• 109013-26-5 5-Amino-N,4-dimethyl-3-phenyl-1H-pyrazol-1-carboxamid 
• 85939-82-8 4-Methyl-5-phenyl-3-pyrazolediazonium Chloride 
• 109013-05-0 3,8-Dimethyl-7-phenyl-pyrazolo<5,1-d>-1,2,3,5-tetrazin-4(3H)-on 
• 109013-04-9 8-Methyl-3,7-diphenyl-pyrazolo<5,1-d>-1,2,3,5-tetrazin-4(3H)-on 
• 85939-75-9 3,7-Diphenyl-8-methylpyrazolo<5,1-c><1,2,4>triazine 
• 78681-01-3 2-Ethoxy-3,3,7-trimethyl-8-phenyl-1,4,5,9-tetraazabicyclo<4.3.0>nona-4,6,8-triene 
• 78681-00-2 4-(Diethylamino)-3,4-dihydro-7-phenyl-3,3,8-trimethylpyrazolo<5,1-c><1,2,4>triazine 
• 78680-98-5 4-(Diethylamino)-3,8-dimethyl-7-phenylpyrazolo<5,1-c><1,2,4>triazine 
• 62072-08-6 3-Diazo-4-methyl-5-phenyl-3H-pyrazol 
• 130598-87-7 2-Ethoxycarbonylmethyl-7-methyl-6-phenyl-1H-imidazo-[1,2-b]pyrazole 
• 1111664-26-6 7-amino-3-methyl-2-phenyl-6-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine 
• 1235890-90-0 3-methyl-7-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-2-phenylpyrazolo[1,5-a]pyrimidine 

Relevant academic research and scientific papers

α-Oxo-Ketenimines from Isocyanides and α-Haloketones: Synthesis and Divergent Reactivity

The palladium-catalyzed reaction of α-haloketones with isocyanides afforded α-oxo-ketenimines through β-hydride elimination of the β-oxo-imidoyl palladium intermediates. Reaction of these relatively stable α-oxo-ketenimines with nucleophiles such as hydrazines, hydrazoic acid, amines, and Grignard reagent afforded pyrazoles, tetrazole, β-keto amidines, and enaminone, respectively, with high chemoselectivity. Whereas amines attack exclusively on the ketenimine functions, the formal [3+2] cycloaddition between N-monosubstituted hydrazines and α-oxo-ketenimines was initiated by nucleophilic addition to the carbonyl group.

Formation and Structure of 1-Amino-4-methyl-4-(4-methyl-5-phenyl1H-pyrazol-3-ylamino)-3-phenyl-4,5-dihydro- 1H-pyrazol-5-one

The title compound 3 was obtained during the rearrangement of isoxazol-5-yl hydrazine 1 to 1-aminopyrazolone 2 at 115°. X-ray analysis of the corresponding benzylidene derivative allowed us to achieve the structure assignment.