6638-23-9

Basic information

• Product Name: 1-{[(4-methylphenyl)amino]methyl}naphthalen-2-ol
• CAS NO: 6638-23-9
• Molecular Formula: C₁₈H₁₇NO
• Molecular Weight: 263.3337
• Mol File: 6638-23-9.mol

Chemical Properties

• Boiling Point: 460.1°C at 760 mmHg
• Flash Point: 163.9°C
• Density: 1.205g/cm³
• Vapor Pressure: 4.37E-09mmHg at 25°C
• Refractive Index: 1.705
• CAS DataBase Reference: 1-{[(4-methylphenyl)amino]methyl}naphthalen-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{[(4-methylphenyl)amino]methyl}naphthalen-2-ol(6638-23-9)
• EPA Substance Registry System: 1-{[(4-methylphenyl)amino]methyl}naphthalen-2-ol(6638-23-9)

Safety Data

• Hazardous Substances Data: 6638-23-9(Hazardous Substances Data)

Usage

Chemical structure

The compound consists of a naphthalene ring fused with a hydroxyl group and a substituted phenylamino group.

Research and chemical analysis

It is commonly used in research and chemical analysis due to its unique structure and properties.

Pharmaceutical industry

It is used in the pharmaceutical industry for the synthesis of various drugs and pharmaceutical intermediates.

Aromatic and hydrophobic nature

The compound is known for its aromatic and hydrophobic nature, making it suitable for use in organic synthesis and as a building block in the production of other chemicals.

Structural features and functional groups

Its structural features and functional groups make it a valuable tool in medicinal chemistry and drug discovery research.

Applications

The compound can be used as a starting material for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.

Solubility

It is likely to be soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), but may have limited solubility in water.

Safety precautions

As with any chemical compound, appropriate safety precautions should be taken when handling 1-[(4-methylphenyl)amino]methylnaphthalen-2-ol, including the use of personal protective equipment (PPE) and proper disposal of waste materials.

Purity

The purity of the compound may vary depending on the synthesis method and purification techniques used, so it is essential to verify the purity before using it in any application.

Upstream product

• 64-17-5 ethanol 
• 32328-79-3 4-methyl-N-methyleneaniline 
• 135-19-3 β-naphthol 
• 17450-22-5 bis(4-methylphenylamino)methane 
• 106-49-0 p-toluidine 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 6639-47-0 1,3,5-tris(p-tolyl)hexahydro-s-triazine 
• 133880-38-3 1-<(4'-methylphenylimino)methyl>-2-naphthol 
• 703-59-3 homophthalic anhydride 
• 6638-21-7 1-[(4-methylphenylimino)methyl]-2-naphthol 
• 50-00-0 formaldehyd 

Downstream Products

• 132034-97-0 2-(1-Pyrrolidinyl)-2,3-dihydro-3-(4-methylphenyl)1H-naphth<1,2-e><1,3,2>oxazaphosphorine 2-sulphide 
• 132035-09-7 2-Piperidin-1-yl-3-p-tolyl-3,4-dihydro-1-oxa-3-aza-2-phospha-phenanthrene 2-sulfide 
• 132035-04-2 2-(3,4-Dimethyl-phenoxy)-3-p-tolyl-3,4-dihydro-1-oxa-3-aza-2-phospha-phenanthrene 2-oxide 
• 132035-02-0 2-(2,5-Dimethyl-phenoxy)-3-p-tolyl-3,4-dihydro-1-oxa-3-aza-2-phospha-phenanthrene 2-oxide 
• 3781-67-7 10-methyl-benzo[a]acridine 
• 6638-21-7 1-[(4-methylphenylimino)methyl]-2-naphthol 
• 1096-84-0 bis(2-hydroxy-1-naphthyl)methane 
• 6638-99-9 1-(2-Amino-4-methylbenzyl)-2-naphthol 
• 132034-96-9 2-Chloro-2,3-dihydro-3-(4-methoxyphenyl)-1H-naphth<1,2-e><1,3,2>oxazaphosphorine 2-sulphide 
• 132034-98-1 2-Hydroxy-2,2'-spirobi<2,3-dihydro-3-(4-methylphenyl)-1H-naphth<1,2-e><1,3,2>oxazaphosphorine> 
• 225-11-6 benz[a]acridine 
• 132034-99-2 2-(2-Chloro-phenoxy)-3-p-tolyl-3,4-dihydro-1-oxa-3-aza-2-phospha-phenanthrene 2-oxide 
• 132034-95-8 2-(3-Methylphenoxy)-2,3-dihydro-3-(4-methylphenyl)-1H-naphth<1,2-e><1,3,2>oxazaphosphorine 2-oxide 
• 132035-01-9 3-p-Tolyl-2-p-tolyloxy-3,4-dihydro-1-oxa-3-aza-2-phospha-phenanthrene 2-oxide 

Relevant articles and documents

Iminium Salts in Solid-State Syntheses Giving 100% Yield

Numerous reaction types in the field of iminium salts are performed in the gas-solid and solid-solid techniques in order to reach 100% yield. The stoichiometric runs are waste-free and do not require costly workup. Frequently, iminium salts were avoided, as acid catalysis was dispensable. Thioureas and α-halogenated ketones give a variety of 2-aminothiazoles via thiuronium salts in quantitative yield. A new intramolecular solid-state thermal condensation is reported. Enaminoketones are synthesized quantitatively from anilines and 1,3-diketones without catalysis and those can be used for quantitative solid-state 4-cascade reactions. Solid paraformaldehyde is used to produce methylene imines and internally trapped methylene iminium salts. Benzoylhydrazones are produced again without catalysis in the solid state. Vacuum and ball-mill techniques are particularly useful in the production of highly sensitive iminium salts. Hexahydro-1,3,5-triazines cyclorevert upon exposure to HCl gas to give solid arylmethylene iminium chlorides as new versatile reagents. These are used in arylaminomethylations of β-naphthol and of themselves to give Troeger's bases in 3-cascades. More direct are 4-cascade Troeger's base syntheses by dissolving hexahydro-1,3,5-triaryltriazines in trifluoroacetic acid. Alkylations of imines with trimethyloxonium tetrafluoroborate and triphenylmethyl cation give highly sensitive quaternary iminium salts in the ball-mill. The products are characterized by spectroscopic techniques and density functional theory (DFT) calculations at the B3LYP 6-31G* level. Molecular movements in the crystal and surface passivation are investigated with atomic force microscopy (AFM) techniques.

Heterocyclic spirocyclohexadienones, II

Hofmann-Martius rearrangement of differently substituted aniline derivatives is investigated and the synthesis of spirocyclohexadienones 5 and 25 is performed. In comparison with 9, a N-aliphatic spiro compound, 5 and 25 give partially different reactions, the cause of which is discussed.

The Condensation of Cyclic Anhydrides with Schiff Bases. A Convenient Synthesis of 1,4,6-Triaryl-5-carboxy-2-oxo-1,2-dihydropyridines and 2,3-Diaryl-4-carboxy-1-oxo-1,2-dihydroisoquinolines

Condensation of Schiff bases of o-hydroxyarenecarboxaldehydes with 3-arylpentenedioic or homophthalic acid anhydrides was found to give 1,4,6-triaryl-5-carboxy-2-oxo-1,2-dihydropyridines and 2,3-diaryl-4-carboxy-1-oxo-1,2-dihydroisoquinolines, respectivel

A General and Practicable Synthesis of Polycyclic Heteroaromatic Compounds. Part 4. A Rationale for the Mechanism of the Synthesis

Studies on aspects of the mechanism of our general synthesis of polycyclic heteroaromatic compounds suggest that the reaction sequence outlined in Scheme 2 is followed.Under the conditions of our synthesis, the ortho-rearrangement (8) --> (9) is preferred to the para-rearrangement which is known to occur in acid conditions.Aniline Mannich bases (29) are converted to benzacridines (30) in an intermolecular reaction.The synthesis appears to be restricted to substrates where the putative intermediate (9) is not part of an amide group.In the course of these studies effective syntheses of the tricyclic compounds (24) and (25) have been discovered.