6638-91-1

Basic information

• Product Name: 2-(PIPERIDINOMETHYL)-1-NAPHTHOL
• Synonyms: 2-(PIPERIDINOMETHYL)-1-NAPHTHOL;2-(piperidin-1-ylmethyl)naphthalen-1-ol
• CAS NO: 6638-91-1
• Molecular Formula: C₁₆H₁₉NO
• Molecular Weight: 241.33
• Mol File: 6638-91-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 134 °C
• Boiling Point: 393.2°C at 760 mmHg
• Flash Point: 198.8°C
• Appearance: /
• Density: 1.158g/cm³
• Vapor Pressure: 9.56E-07mmHg at 25°C
• Refractive Index: 1.644
• PKA: 9.74±0.50(Predicted)
• CAS DataBase Reference: 2-(PIPERIDINOMETHYL)-1-NAPHTHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PIPERIDINOMETHYL)-1-NAPHTHOL(6638-91-1)
• EPA Substance Registry System: 2-(PIPERIDINOMETHYL)-1-NAPHTHOL(6638-91-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 6638-91-1(Hazardous Substances Data)

Usage

General Description

2-(piperidinomethyl)-1-naphthol is a chemical compound with the molecular formula C17H19NO. It consists of a naphthol group, which is a type of aromatic alcohol, attached to a piperidinomethyl group, which contains a piperidine ring. 2-(PIPERIDINOMETHYL)-1-NAPHTHOL is often used in research and pharmaceutical applications as a building block in the synthesis of various organic molecules. It may also have potential uses in the development of new drugs or as a catalyst in chemical reactions. Additionally, its unique structure and properties make it a valuable tool for investigating the behavior of organic compounds in different environments.

InChI:InChI=1/C16H19NO/c18-16-14(12-17-10-4-1-5-11-17)9-8-13-6-2-3-7-15(13)16/h2-3,6-9,18H,1,4-5,10-12H2

Upstream product

• 110-89-4 piperidine 
• 50-00-0 formaldehyd 
• 64-17-5 ethanol 
• 90-15-3 α-naphthol 
• 3275-13-6 1-(ethoxymethyl)piperidine 
• 880-09-1 di(N-piperidinyl)methane 
• 606-41-7 2-amino-1-naphthol 

Downstream Products

• 952008-22-9 4-nitro-benzoic acid-(2-piperidinomethyl-[1]naphthyl ester) 

Relevant articles and documents

An amino-naphthol preparation method of compound

The invention relates to a preparation method for aminonaphthol compound. The method includes the following steps: catalyst, aldehyde compound, secondary amine compound and naphthol are sequentially added into water and react under the temperature condition of 20 DEG C to 80 DEG C, and after reaction is complete, reaction liquid is obtained; the reaction liquid is sequentially extracted, dried, concentrated and separated by column chromatography according to the conventional method, so that product I or product II is obtained, and the structural formula of the product is shown in the figure. The preparation method has the advantages of mild conditions, short reaction time, simple post-processing, high yield and environment-friendliness, can realize mass production and has a good industrial application prospect.

Exploiting tautomerism for switching and signaling

Good form: Attaching a flexible piperidine unit to 4-(phenyldiazenyl) naphthalen-1-ol allows construction of a tautomeric switch, where directed shift of the tautomeric equilibrium can be achieved through protonation and deprotonation (see picture). The developed molecular switch shows acceptable complexation with small alkali- and alkaline-earth-metal ions and forms a promising base for further development of effective molecular sensors.

Intramolecular Interactions I. The Use of Some Mannich Bases of Naphthols as Model Compounds for Intramolecular Hydrogen Bonding

Some model compounds for intramolecular hydrogen bonding are presented.The nmr, IR, UV and fluorescence spectra are shown to be suited for the study of such hydrogen bonds. - Keywords: Hydrogen bond; Intramolecular proton transfer; Mannich bases