663932-06-7Relevant academic research and scientific papers
Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors
Ma, Dawei,Wu, Wengen,Yang, Guoxin,Li, Jingya,Li, Jia,Ye, Qizhuang
, p. 47 - 50 (2007/10/03)
The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups.
