66396-17-6Relevant academic research and scientific papers
Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine
Milian, Lara,Estelles, Rossana,Abarca, Belen,Ballesteros, Rafael,Sanz, Maria Jesus,Blazquez, Maria Amparo
, p. 696 - 699 (2004)
Four phenanthrene and one aporphine alkaloids semi-synthesized from boldine were evaluated for their inhibitory effect on reactive oxygen species (ROS) generation. ROS generation by neutrophils stimulated with N-formyl-methionyl- leucyl-phenylalanine was inhibited in a concentration dependent manner. Alkaloids exerted similar inhibitory effect in the hypoxanthine-xanthine oxidase system than in stimulated neutrophils, which could be attributed to a direct ROS scavenging activity. None of the alkaloids assayed had any effect on xanthine oxidase activity. Therefore the synthesized alkaloids might constitute an alternative therapy in inflammation disorders in which ROS generation is involved.
TRANSFORMATION FROM APORPHINE N-OXIDES TO 1-(N-METHYL-N-HYDROXYLAMINOETHYL)PHENANTHRENE DERIVATIVES
Lu, Sheng-Teh,Wu, Yang-Chang
, p. 3085 - 3094 (2007/10/02)
Heat treatment of aporphine N-oxides prepared by the m-chloroperbenzoic acid (m-CPBA) oxidation of aporphines afforded 1-(N-methyl-N-hydroxylaminoethyl)phenanthrene derivatives which were characterized by the physical and chemical evidences.The biogenetic pathway from aporphines to phenanthrenes is also discussed.
