66396-17-6

Basic information

• Product Name: 8-(2-Dimethylamino-ethyl)-3,5-dimethoxy-phenanthrene-2,6-diol
• CAS NO: 66396-17-6
• Molecular Weight: 341.407
• Mol File: 66396-17-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-(2-Dimethylamino-ethyl)-3,5-dimethoxy-phenanthrene-2,6-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(2-Dimethylamino-ethyl)-3,5-dimethoxy-phenanthrene-2,6-diol(66396-17-6)
• EPA Substance Registry System: 8-(2-Dimethylamino-ethyl)-3,5-dimethoxy-phenanthrene-2,6-diol(66396-17-6)

Safety Data

• Hazardous Substances Data: 66396-17-6(Hazardous Substances Data)

Upstream product

• 476-70-0 boldine 
• 104385-34-4 (S)-1,10-Dimethoxy-6-methyl-6-oxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol 
• 104385-42-4 8-[2-(Hydroxy-methyl-amino)-ethyl]-3,5-dimethoxy-phenanthrene-2,6-diol 
• 50-00-0 formaldehyd 
• 66396-12-1 secoboldine 

Relevant articles and documents

Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine

Four phenanthrene and one aporphine alkaloids semi-synthesized from boldine were evaluated for their inhibitory effect on reactive oxygen species (ROS) generation. ROS generation by neutrophils stimulated with N-formyl-methionyl- leucyl-phenylalanine was inhibited in a concentration dependent manner. Alkaloids exerted similar inhibitory effect in the hypoxanthine-xanthine oxidase system than in stimulated neutrophils, which could be attributed to a direct ROS scavenging activity. None of the alkaloids assayed had any effect on xanthine oxidase activity. Therefore the synthesized alkaloids might constitute an alternative therapy in inflammation disorders in which ROS generation is involved.