66399-01-7

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-3-NITROBENZALDEHYDE OXIME is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and medicinal compounds.
Used in Dye Industry:
In the dye industry, 4-CHLORO-3-NITROBENZALDEHYDE OXIME is used as a precursor in the production of various dyes, providing color and stability to textiles and other materials.
Used in Agrochemical Industry:
4-CHLORO-3-NITROBENZALDEHYDE OXIME is utilized as a raw material in the manufacturing of agrochemicals, contributing to the development of pesticides and other agricultural chemicals to protect crops and enhance yield.
Used in Rubber Chemical Industry:
As a raw material in the rubber chemical industry, 4-CHLORO-3-NITROBENZALDEHYDE OXIME is used in the production of rubber additives, improving the properties and performance of rubber products.
Used in Antioxidant Production:
4-CHLORO-3-NITROBENZALDEHYDE OXIME is used as a component in the synthesis of antioxidants, which are essential in preventing the oxidation of materials and extending their shelf life.
Used in Corrosion Inhibitor Industry:
In the corrosion inhibitor industry, 4-CHLORO-3-NITROBENZALDEHYDE OXIME is used as a raw material for the development of corrosion inhibitors, protecting metals and other materials from corrosion and degradation.
Used in Organic Synthesis:
4-CHLORO-3-NITROBENZALDEHYDE OXIME is used as a reagent in organic synthesis, facilitating various chemical reactions and contributing to the production of fine chemicals and other specialty compounds.

InChI:InChI=1/C7H5ClN2O3/c8-6-2-1-5(4-9-11)3-7(6)10(12)13/h1-4,11H/b9-4-

Upstream product

• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 79-24-3 Nitroethane 

Downstream Products

• 160192-82-5 4-chloro-3-nitro-N-hydroxy-benzimoyl chloride 
• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 1217551-02-4 N′-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chlorophenyl}benzohydrazide 
• 1237587-33-5 N′-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chlorophenyl}isonicotinohydrazide 
• 1237587-35-7 4,4-dimethyl-1-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chlorophenyl}semicarbazide 
• 1237587-36-8 4-ethyl-1-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chlorophenyl}semicarbazide 
• 1237587-37-9 N'-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chlorophenyl}phenylacetohydrazide 
• 1237587-38-0 tert-butyl N′-acryloyl-N-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate 
• 1237587-39-1 N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}acrylohydrazide 
• 1237587-44-8 tert-butyl N′-(4-bromobutyryl)-N-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate 
• 1237587-46-0 tert-butyl N'-(5,5,5-trifluoropentanoyl)-N-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate 
• 1237587-52-8 N′-{5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-chlorophenyl}-4-nitrobenzohydrazide 
• 1237587-57-3 tert-butyl N'-(4-methoxybenzoyl)-N-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}carbazate 
• 1237587-58-4 N′-{2-chloro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]phenyl}-4-methoxybenzohydrazide 

Relevant academic research and scientific papers

Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors

Factor Xa (fXa) is an important serine protease in the blood coagulation cascade. Inhibition of fXa has emerged as an attractive target for potential therapeutic applications in the treatments of both arterial and venous thrombosis. Herein, we describe a series of non-benzamidine isoxazoline derivatives as fXa inhibitors. The chloroaniline group was found to be the most potent benzamidine mimic in this series. Chloroaniline 1 (ST368) has a Ki value of 1.5 nM against fXa and is highly selective for fXa relative to thrombin and trypsin.

Discovery of 3-amino-4-chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library

In an effort to identify orally bioavailable factor Xa inhibitors, two isoxazolines libraries were prepared to scan for novel P1 ligands. From this work, 4-chloro-3-aniline was identified as a novel and potent benzamidine mimic.

HENRY CONDENSATION UNDER HIGH PRESSURE. 2. EFFECT OF AROMATIC ALDEHYDE TYPE AND PRESSURE ON THE YIELD OF ω-NITROSTYRENES AND SECONDARY PROCESSES

Condensation of aromatic aldehydes (I)-(XX) with EtNO2 and n-PrNO2 in AcOH in the presence of AcONH4 or i-BuNH2 gives primarily ω-nitrostyrenes (Ia, b) - (XXa, b) and small quantities of nitriles (Ic) - (XXc), oximes (Id) - (XXd), and ketones (Ie, f) - (XXe, f).The yields of (Ia, b) - (XXa, b) at P = 1 atm are higher for acceptor substitutents on the aromatic ring whereas at P = 10 kbar, they are higher for donor substituents.High pressures suppress the formation of (Ic-f) - (XXc-f) and the Z-isomers of (Ia, b) - (XXa, b).The high pressure technique is especially useful in the preparation of donor-substituted (Ia, b) - (XXa, b) which are intermediates in the synthesis of the psychotropic β-phenylethylamines.