66400-18-8

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 6-chloro-1,3-dicyclohexyl-
• CAS NO: 66400-18-8
• Molecular Formula: C16H23ClN2O2
• Molecular Weight: 310.824
• Mol File: 66400-18-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 6-chloro-1,3-dicyclohexyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 6-chloro-1,3-dicyclohexyl-(66400-18-8)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 6-chloro-1,3-dicyclohexyl-(66400-18-8)

Safety Data

• Hazardous Substances Data: 66400-18-8(Hazardous Substances Data)

Upstream product

• 35824-91-0 1,3-dicyclohexyl barbituric acid 

Downstream Products

• 72820-31-6 1,3-dicyclohexyl-6-hydrazino-1H-pyrimidine-2,4-dione 
• 66400-25-7 1,3-dicyclohexyl-6-methylamino-1H-pyrimidine-2,4-dione 
• 506437-17-8 N-(1,3-dicyclohexyl-5-nitroso-6-uracilyl)-S,S-diphenylsulfilimine 
• 506437-14-5 C₂₈H₃₃N₃O₂S 

Relevant articles and documents

Synthesis of pyrimidine derivatives possessing an antioxidative property and their inhibitory effects on picryl chloride-induced contact hypersensitivity reaction

We conducted a preliminary structure-activity relationship (SAR) study of some barbituric acid and uracil derivatives against the picryl chloride-induced contact hypersensitivity reaction. The introduction of an antioxidative moiety to the side chain of the C(6)-position of uracil was effective against this model. The introduction of dimethoxyphenol (8b) or dimethylphenol (8c) instead of di-t-butylphenol (8a) as an antioxidative moiety gave diminished activities, so, the reactive oxygen would contribute to the inflammation of this model, and an antioxidative activity was required for exhibiting the inhibitory activity. The inhibitory activity was significantly affected by the substituent at the N(1)-phenyl moiety.

Xanthine derivatives, process for their preparation and pharmaceutical compositions

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