66408-36-4

Usage

Uses

Used in Pharmaceutical Industry:
(+/-)-Nor-β-hydrastine is used as a GABAergic receptor-binding agent for its potential therapeutic applications in the treatment of various neurological and psychiatric disorders. Its ability to interact with GABAergic receptors suggests that it may have anxiolytic, sedative, and anticonvulsant properties, making it a promising candidate for the development of new drugs to address these conditions.
Used in Research and Development:
(+/-)-Nor-β-hydrastine is also used as a research tool in the field of neuroscience to study the function and regulation of GABAergic receptors. This can help researchers gain a better understanding of the underlying mechanisms of various neurological and psychiatric disorders, as well as the potential therapeutic effects of GABAergic receptor-binding compounds.

Upstream product

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Relevant academic research and scientific papers

An Acid-Catalyzed Epoxide Ring-Opening/Transesterification Cascade Cyclization to Diastereoselective Syntheses of (±)-β-Noscapine and (±)-β-Hydrastine

An acid-catalyzed stereoselective epoxide ring-opening/intramolecular transesterification cascade cyclization reaction and N-Boc deprotection was found to be a successful strategy to construct the phthalide tetrahydroisoquinoline skeleton in one pot. Based on this strategy, the unified and highly diastereoselective routes for the total syntheses of (±)-β-Noscapine and (±)-β-Hydrastine were exploited.

Diastereoselektive Hydroxyalkylierungen in 1-Stellung von Tetrahydroisochinolinen und Synthese von Aporphin-, Protoberberin- und Phthalid-Alkaloiden

Unsubstituted and 6,7-dialkyloxy-N-pivaloyl-tetrahydroisoquinolines 1-3 are converted to 1-bromomagnesium derivatives by sequential treatment with t-BuLi (-75 deg C/THF) and MgBr2*OEt2.Addition of the metalated tetrahydroisoquinolines to aliphatic or arom

A Pyrolytic Route to the Phthalide-Isoquinolines

Pyrolysis of 8,13-dioxo-14-methoxycanadine (5) yields methyl keto ester 11 (35percent), aromatic phthalide-isoquinoline 12 (15percent), and (+)-chilenine (13, 7percent).Methyl keto ester 11 can be reduced quantitatively to 12 with sodium borhydride.Cataly