66414-17-3 Usage
General Description
4-PIPERIDIN-4-YLMETHYL-PHENOL is an organic compound that consists of a phenol group attached to a piperidine ring. It is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. This chemical has applications in the production of antihistamines, antipsychotics, and other psychoactive drugs. It can also be utilized in the synthesis of insecticides and herbicides. Additionally, 4-PIPERIDIN-4-YLMETHYL-PHENOL is employed as an intermediate in the manufacturing of dyes and coatings. Due to its diverse applications, this compound is of interest in the fields of medicinal chemistry, organic synthesis, and chemical manufacturing.
Check Digit Verification of cas no
The CAS Registry Mumber 66414-17-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,4,1 and 4 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 66414-17:
(7*6)+(6*6)+(5*4)+(4*1)+(3*4)+(2*1)+(1*7)=123
123 % 10 = 3
So 66414-17-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO/c14-12-3-1-10(2-4-12)9-11-5-7-13-8-6-11/h1-4,11,13-14H,5-9H2
66414-17-3Relevant articles and documents
Identification and development of an efficient route to SB-649915
Armitage, Mark,Bret, Guillaume,Choudary, Bernie M.,Kingswood, Mike,Loft, Mike,Moore, Steve,Smith, Steve,Urquhart, Michael W. J.
, p. 1626 - 1634 (2013/02/22)
The discovery and development of an efficient manufacturing route to the SSRI-5-HT1A receptor antagonist 6-[(1-{2-[(2-methyl-5-quinolinyl)oxy]ethyl}-4- piperidinyl)methyl]-2H-1,4-benzoxazin-3(4H)-one (SB-649915) 1 is described. The existing route to 1 involved coupling quinoline 6 with piperidine 5 and was considered lengthy as a consequence of the nine synthetic steps required to prepare 5. Two new routes to the key piperidine intermediate 5 are identified which deliver this compound in five and two steps respectively, from readily available materials using novel lithiation and Friedel-Crafts methodology respectively. The latter of these two routes was successfully demonstrated at 5 L scale to deliver 700 g of 5. Development to the methanesulfonate 34, an alternative to quinoline 6, is also described as is the final alkylation of piperidine 5 with this methanesulfonate 34 to deliver SB-649915 1.
