66416-73-7

Basic information

• Product Name: 4-AMino-3-iodophenol
• Synonyms: 4-AMino-3-iodophenol
• CAS NO: 66416-73-7
• Molecular Formula: C₆H₆INO
• Molecular Weight: 235
• Mol File: 66416-73-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 145.5 °C
• Boiling Point: 357.8±37.0 °C(Predicted)
• Appearance: /
• Density: 2.094±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 9.37±0.18(Predicted)
• CAS DataBase Reference: 4-AMino-3-iodophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMino-3-iodophenol(66416-73-7)
• EPA Substance Registry System: 4-AMino-3-iodophenol(66416-73-7)

Safety Data

• Hazardous Substances Data: 66416-73-7(Hazardous Substances Data)

Usage

General Description

4-Amino-3-iodophenol is a chemical compound with the molecular formula C6H6INO. It is a derivative of phenol and contains an amino group and an iodine atom attached to the benzene ring. 4-AMino-3-iodophenol is commonly used as a reagent in organic synthesis and as a building block for the preparation of various pharmaceuticals and dyes. It has been studied for its potential biological activities, including antioxidant and anti-inflammatory properties. 4-Amino-3-iodophenol is a yellow solid that is sparingly soluble in water and soluble in organic solvents, and it should be handled and stored with care due to its hazardous nature.

Upstream product

• 50590-07-3 3-iodo-4-nitrophenol 
• 41319-82-8 2-iodophenyl hydroxylamine 
• 305-80-6 4-diazobenzenesulfonic acid 
• 626-02-8 3-Iodophenol 

Downstream Products

• 388564-62-3 (4-hydroxy-2-iodo-phenyl)-carbamic acid benzyl ester 
• 191348-14-8 2-iodo-4-methoxylaniline 
• 157496-75-8 tert-butyl (2-iodo-4-methoxyphenyl)carbamate 
• 212063-22-4 N-carbobenzyloxy-4-methoxy-2-iodoaniline 
• 22944-04-3 siccayne diacetate 
• 22944-03-2 Siccayne 
• 496881-71-1 2-iodohydroquinone diacetate 
• 315179-94-3 4-methoxy-2-(1-propynyl)phenyl isocyanate 

Relevant articles and documents

Total synthesis of ibogaine, epiibogaine and their analogues

Efficient total synthesis of ibogaine, epiibogaine and their analogues has been described. An intramolecular reductive-Heck type cyclization was used for the construction of seven-membered indoloazepine ring to access iboga-skeleton. Larock's heteroannula

Kinetics and Mechanism of the Bamberger Rearrangement. Part 4. Rearrangement of Sterically Hindered Phenylhydroxylamines to 4-Aminophenols in Aqueous Sulphuric Acid Solution

The rates of the Bamberger rearrangement of sterically hindered phenylhydroxylamines have been determined in aqueous sulphuric acid solution and the substituent effects (in particular, the steric effects) are discussed.The rate constants for phenylhydroxylamines with 2-substituents (Me, Cl, I) satisfied the Taft equation: log krel = ρ*?* - δES with ρ*-1.93 and δ-1.16.The result shows that steric hindrance of the substituents, in addition to the electron-donating effect, has an accelerating effect on the rates of the Bamberger rearrangement.The rate constants for 3-substituted 2-methylphenylhydroxylamines were generally greater than those for 5-substituted 2-methylphenylhydroxylamines.The difference was attributed to the 'buttressing effect' of neighbouring 3-substituents.This is the first example of steric acceleration of the Bamberger rearrangement.